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Researchers find low-dose PET/CT best imaging method for lymphoma

By Rebekah Moan | December 4, 2008

Low-dose PET/CT demonstrates the best sensitivity and specificity for initial staging of lymphoma, according to a study presented on Thursday at the RSNA meeting.

Dr. Immaculada Pinilla Fernandez, from the University Hospital La Paz in Madrid, Spain, and colleagues prospectively studied 108 consecutive patients with biopsy-proven non-Hodgkin's lymphoma as well as Hodgkin's lymphoma. The patients underwent initial staging with F-18 FDG-PET/CT that included a low-dose CT and a PET study followed by a full-dose, contrast-enhanced CT.

Low-dose PET/CT correctly classified lymphoma stage in 77.5% of patients, while PET correctly classified 65.6% and contrast-enhanced CT identified 63%. The researchers found the sensitivity and specificity of low-dose PET/CT to be 94.8% and 90.5%, respectively. The positive and negative predictive values were 93% and 92%. PET sensitivity and specificity was 90% and 86%. Sensitivity and specificity for CT was 88% and 90%.

Since low-dose PET/CT achieved the best sensitivity and specificity, radiation dose could be reduced and use of intravenous iodinated contrast material could be avoided in patients with lymphoma, Fernandez said.

 

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RSNA 2008 CT Scanning

Radiation dose awareness leads to more pediatric referrals for ultrasound and MRI
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Educational efforts to raise awareness about the associated risks of CT-based radiation exposure and the need to keep children from receiving unnecessary scans seem to be achieving traction among healthcare providers, according to a study by Ohio researchers. Their findings suggest that such increased awareness may make referring physicians less likely to order imaging that involves ionizing radiation for young patients.

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A low-cost 16-slice scanner designed for cost-constrained customers debuted at the Philips booth during the RSNA meeting.

McFarland plots course toward acceptance of CT colonography
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In the aftermath of Medicare’s less than encouraging evaluation of virtual CT colonography for colorectal cancer screening, Dr. Elizabeth McFarland used the RSNA’s Annual Oration in Diagnostic Radiology to identify past achievements and ongoing initiatives she believes will lead to the modality’s acceptance.

Researchers find low-dose PET/CT best imaging method for lymphoma
December 4, 2008

Low-dose PET/CT demonstrates the best sensitivity and specificity for initial staging of lymphoma, according to a study presented on Thursday at the RSNA meeting.

Studies attest to prognostic value of coronary CTA
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