JUNE 2003

Molecular imaging resources

Primers aid physician self-education


Molecular imaging
Dr. Ralph Weissleder, Dr. Umar Mahmood
Massachusetts General Hospital
Radiology 2001;219:316-333
Defines molecular imaging, identifies its potential role, and describes various lines of research that may lead to clinical applications.

Molecular imaging in vivo with PET and SPECT
Dr. Gary D. Luker, Dr. David Piwnica-Worms
Washington University Medical School, St. Louis
Acad Radiol 2001;8:4-14
Examines potential roles for nuclear medicine in molecular imaging and research that is laying the foundation for clinical applications.

Molecular imaging of cancer with PET
Dr. Sanjiv (Sam) Gambhir
University of California, Los Angeles; Stanford University
Nature Reviews 2002;2:683-693
Examines basic and advanced PET applications, including FDG utilization and gene therapy.

Gene therapy: a primer for radiologists
Dr. S.D. Voss, Jonathan B. Kruskal
Beth Israel Deaconess Medical Center
RadioGraphics 1998;18:1343-1372
Explains how oncogenes, tumor suppressors, immunostimulatory cytokines, costimulatory molecular, and antiangiogenesis genes are used to fight disease.

Molecular imaging: an overview
Dr. Martin G. Pomper
Johns Hopkins University School of Medicine
Academic Radiology 2001;8:1141-1153
Reports the status and potential of molecular imaging and assesses its relevance to clinical practice.

Molecular imaging and gene therapy
Dr. Carolyn Nichol, Dr. E. Edmund Kim
M.D. Anderson Cancer Center, Houston
Journal of Nuclear Medicine 2001;42:1368-1374
Examines the use of nuclear medicine, MRI, and optical imaging to visualize gene expression and evaluate disease on a cellular level.