Top: Optical coherence tomography from cadaver studies shows plaque with lipid pool and thin fibrous cap. Lesion would not be apparent on angiography as it does not intrude into lumen.
(Provided by LightLab Imaging)

Bottom: Noncontrast MR shows large, eccentric plaque (arrow) in left anterior descending (LAD) coronary artery. Variable signal intensity can identify vulnerable plaque at risk of rupture.
(Provided by Z. Fayad)