Choosing an iso-osmolar dimeric contrast agent can reduce the risk of damage to kidneys in patients with diabetes or impaired renal function, according to a multinational study. Researchers in 17 centers evaluated serum creatinine output for 135
Choosing an iso-osmolar dimeric contrast agent can reduce the risk of damage to kidneys in patients with diabetes or impaired renal function, according to a multinational study.
Researchers in 17 centers evaluated serum creatinine output for 135 patients with impaired kidney function in a double-blinded study of iodixanol, an iso-osmolar nonionic dimeric contrast medium, and iohexol, a low-osmolar nonionic monomeric contrast medium.
Compared with a baseline reading, patients given iodixanol had an average peak increase of 11.2 mmol/L of creatinine during the next three days. For patients given iohexol, the increase was 48.2 mmol/L. Only 3% of patients given iodixanol crossed the threshold for nephrotoxicity, compared with 26.2% for iohexol patients.
The result, according to lead author Dr. Peter Aspelin of Huddinge University Hospital in Stockholm, was that patients given iodixanol were 11 times less likely to experience nephrotoxicity. The findings of the Nephrotoxicity in High Risk Patients study were published recently in the New England Journal of Medicine and presented at the European Congress of Radiology.
"The risk of nephropathy is already high in patients with diabetes mellitus," he said. "Iodixanol can lower that risk."
MRI-Based AI Radiomics Model Offers 'Robust' Prediction of Perineural Invasion in Prostate Cancer
July 26th 2024A model that combines MRI-based deep learning radiomics and clinical factors demonstrated an 84.8 percent ROC AUC and a 92.6 percent precision-recall AUC for predicting perineural invasion in prostate cancer cases.
Breast MRI Study Examines Common Factors with False Negatives and False Positives
July 24th 2024The absence of ipsilateral breast hypervascularity is three times more likely to be associated with false-negative findings on breast MRI and non-mass enhancement lesions have a 4.5-fold likelihood of being linked to false-positive results, according to new research.
Can Polyenergetic Reconstruction Help Resolve Streak Artifacts in Photon Counting CT?
July 22nd 2024New research looking at photon-counting computed tomography (PCCT) demonstrated significantly reduced variation and tracheal air density attenuation with polyenergetic reconstruction in contrast to monoenergetic reconstruction on chest CT.