University of Pittsburgh researchers found preclinical success with an artificial blood vessel engineered from muscle-derived stem cells and a biodegradable polymer. Results could benefit the treatment of heart and kidney diseases, which need new sources of blood vessels for vascular grafts.
University of Pittsburgh researchers found preclinical success with an artificial blood vessel engineered from muscle-derived stem cells and a biodegradable polymer. Results could benefit the treatment of heart and kidney diseases, which need new sources of blood vessels for vascular grafts.
According to Alejandro Nieponice, Ph.D., and colleagues, saphenous vein coronary artery bypass grafts often fail, and arterial grafts, while less prone to become obstructed, are in limited supply as many patients require multiple grafts. Thus, a need exists for a small-caliber arterial substitute for revascularization procedures.
Results of the study, presented at the 2007 Tissue Engineering and Regenerative Medicine International Society meeting, showed that cell-seeded grafts in rats had significantly less blockage than controls and exhibited extensive remodeling consistent with a mature artery. Researchers said that grafts made from a patient's own stem cells could be ready almost immediately, which "suggests that we could make these available 'off-the-shelf,' an essential element for clinical translation."
MRI-Based AI Radiomics Model Offers 'Robust' Prediction of Perineural Invasion in Prostate Cancer
July 26th 2024A model that combines MRI-based deep learning radiomics and clinical factors demonstrated an 84.8 percent ROC AUC and a 92.6 percent precision-recall AUC for predicting perineural invasion in prostate cancer cases.
Breast MRI Study Examines Common Factors with False Negatives and False Positives
July 24th 2024The absence of ipsilateral breast hypervascularity is three times more likely to be associated with false-negative findings on breast MRI and non-mass enhancement lesions have a 4.5-fold likelihood of being linked to false-positive results, according to new research.
Can Polyenergetic Reconstruction Help Resolve Streak Artifacts in Photon Counting CT?
July 22nd 2024New research looking at photon-counting computed tomography (PCCT) demonstrated significantly reduced variation and tracheal air density attenuation with polyenergetic reconstruction in contrast to monoenergetic reconstruction on chest CT.