There is high diagnostic accuracy when grading gliomas with dynamic contrast material–enhanced (DCE) and dynamic susceptibility contrast (DSC) MR imaging.
Dynamic contrast material–enhanced (DCE) and dynamic susceptibility contrast (DSC) magnetic resonance (MR) provide comparable, high diagnostic accuracy for grading gliomas, according to a study published in the journal Radiology.
Researchers from Italy and the United States sought to evaluate the feasibility of a standardized protocol for acquisition and analysis of DCE and DSC-MR imaging setting and to verify its accuracy in predicting glioma grade according to the new World Health Organization 2016 classification.
A total of 100 patients with glioma were prospectively examined at 3 T in seven centers that performed the same preoperative MR imaging protocol, including DCE and DSC sequences. Two independent readers identified the perfusion hotspots on maps of volume transfer constant (Ktrans), plasma (vp) and extravascular-extracellular space (ve) volumes, initial area under the concentration curve, and relative cerebral blood volume (rCBV). Differences in parameters between grades and molecular subtypes were assessed by using Kruskal-Wallis and Mann-Whitney U tests. All patients tolerated the protocol.
The results included successfully obtained perfusion maps in 94 patients.
“An excellent interreader reproducibility of DSC- and DCE-derived measures was found,” the authors wrote. Among DCE-derived parameters, vp and ve had the highest accuracy (are under the receiver operating characteristic curve [Az] = 0.847 and 0.853) for glioma grading. DSC-derived rCBV had the highest accuracy (Az = 0.894), but the difference was not statistically significant.
Among lower-grade gliomas, a moderate increase in both vp and rCBV was evident in isocitrate dehydrogenase wild-type tumors, although this was not significant.
The researchers concluded that a standardized multicenter acquisition and analysis protocol of DCE and DSC MR imaging is feasible and highly reproducible, with both techniques showing a comparable, high diagnostic accuracy for grading gliomas.
Emerging AI Algorithm Shows Promise for Abbreviated Breast MRI in Multicenter Study
April 25th 2025An artificial intelligence algorithm for dynamic contrast-enhanced breast MRI offered a 93.9 percent AUC for breast cancer detection, and a 92.3 percent sensitivity in BI-RADS 3 cases, according to new research presented at the Society for Breast Imaging (SBI) conference.
The Reading Room Podcast: Current Perspectives on the Updated Appropriate Use Criteria for Brain PET
March 18th 2025In a new podcast, Satoshi Minoshima, M.D., Ph.D., and James Williams, Ph.D., share their insights on the recently updated appropriate use criteria for amyloid PET and tau PET in patients with mild cognitive impairment.
Can Abbreviated Breast MRI Have an Impact in Assessing Post-Neoadjuvant Chemotherapy Response?
April 24th 2025New research presented at the Society for Breast Imaging (SBI) conference suggests that abbreviated MRI is comparable to full MRI in assessing pathologic complete response to neoadjuvant chemotherapy for breast cancer.
Clarius Mobile Health Unveils Anterior Knee Feature for Handheld Ultrasound
April 23rd 2025The T-Mode Anterior Knee feature reportedly offers a combination of automated segmentation and real-time conversion of grayscale ultrasound images into color-coded visuals that bolster understanding for novice ultrasound users.