Enhanced MRI Improves Prostate Cancer Imaging

January 9, 2015

Magnetic resonance imaging with restriction spectrum imaging may help clinicians better identify prostate cancer staging.

Enhanced MRI diffusion with restriction spectrum imaging (RSI-MRI) shows promise for substantially improving prostate cancer imaging, according to a study published in the journal Prostate Cancer and Prostatic Disease.

Researchers from the University of California, San Diego School of Medicine, and the University of California, Los Angeles, developed a novel, enhanced MRI diffusion technique using restriction spectrum imaging and compared its efficacy with standard MRI for detecting extraprostatic extension (EPE).

Twenty-seven patients with prostate cancer who underwent MRI and RSI-MRI prior to radical prostatectomy were evaluated. Ten patients had histologically proven pT3 disease.[[{"type":"media","view_mode":"media_crop","fid":"30855","attributes":{"alt":"Rebecca Rakow-Penner, MD, PhD","class":"media-image media-image-right","id":"media_crop_6210645127716","media_crop_h":"0","media_crop_image_style":"-1","media_crop_instance":"3242","media_crop_rotate":"0","media_crop_scale_h":"0","media_crop_scale_w":"0","media_crop_w":"0","media_crop_x":"0","media_crop_y":"0","style":"border-width: 0px; border-style: solid; margin: 1px; float: right;","title":"Rebecca Rakow-Penner, MD, PhD","typeof":"foaf:Image"}}]]

The results showed that the standard preoperative MRI correctly identified extraprostatic extension in two patients (22%) of the nine with pT2. The RSI-MRI identified EPE in eight of the nine patients (89%), and the technique also correctly identified pT2 disease in the remaining 18 patients.

"This new approach is a more reliable imaging technique for localizing tumors. It provides a better target for biopsies, especially for smaller tumors," first author Rebecca Rakow-Penner, MD, PhD, research resident in the Department of Radiology, University of California San Diego, said in a release.

The researchers concluded that although more research is needed, their RSI-MRI technology was feasible and showed promise in imaging for prostate cancer.