• AI
  • Molecular Imaging
  • CT
  • X-Ray
  • Ultrasound
  • MRI
  • Facility Management
  • Mammography

Exercise, Diet in Knee Cartilage Deterioration


Effect of diet, exercise on people who are overweight or obese who lose weight to help decrease knee cartilage deterioration.

Magnetic resonance images show that how people lose weight has an impact on slowing down knee cartilage degeneration, according to a study presented at RSNA.

Researchers from the United States investigated cartilage degeneration and joint abnormalities in overweight and obese subjects who maintained stable weight and who lost weight via differing regimens. A total of 760 subjects (295 men and 465 women) were recruited from the Osteoarthritis Initiative. All had a BMI of greater than 25kg/m2 and mild to moderate osteoarthritis or risk factors for the disease. The subjects were divided into two groups of 380 each, one group that lost weight, and a control group of 380 patients that lost no weight. The weight-loss group was further divided by weight loss method: diet and exercise, diet alone, and exercise alone. The subjects all underwent right knee MR imaging to quantify knee osteoarthritis at the beginning of the study, at 48 months, and at 96 months.

The researchers evaluated T2 relaxation time changes of cartilage composition, including laminar and texture analysis as well as morphological knee abnormalities, assessed with Whole-Organ-Magnetic-Resonance-Imaging-Scores (WORMS).

The results showed progression of cartilage WORMS was significantly lower in the weight loss group compared to controls over 96 months. Subjects with weight loss showed significantly less T2-value increase in the bone layer of all compartments compared to the controls with stable weight, suggesting less cartilage degeneration over 96 months in the subjects with weight loss compared to their controls. Rates of increase in cartilage T2 averaged over all compartments were lowest in the diet and diet and exercise groups compared to the stable weight group. Weight loss through exercise alone showed no significant difference in change of T2 over 96 months compared to subjects with stable weight.

“These results add to the hypothesis that solely exercise as a regimen in order to lose weight in overweight and obese adults may not be as beneficial to the knee joint as weight loss regimens involving diet,” lead author, Alexandra Gersing, MD, from the Department of Radiology and Biomedical Imaging at the University of California, San Francisco, said in a release.

[[{"type":"media","view_mode":"media_crop","fid":"64649","attributes":{"alt":"","class":"media-image","id":"media_crop_7328331501829","media_crop_h":"0","media_crop_image_style":"-1","media_crop_instance":"8274","media_crop_rotate":"0","media_crop_scale_h":"0","media_crop_scale_w":"0","media_crop_w":"0","media_crop_x":"0","media_crop_y":"0","title":"Baseline and follow-up MRIs of the right knee of two obese women, one who lost no weight (A, B), and one who lost weight (C, D). ©RSNA 2017","typeof":"foaf:Image"}}]]

Recent Videos
Where the USPSTF Breast Cancer Screening Recommendations Fall Short: An Interview with Stacy Smith-Foley, MD
A Closer Look at MRI-Guided Transurethral Ultrasound Ablation for Intermediate Risk Prostate Cancer
Improving the Quality of Breast MRI Acquisition and Processing
Can Diffusion Microstructural Imaging Provide Insights into Long Covid Beyond Conventional MRI?
Assessing the Impact of Radiology Workforce Shortages in Rural Communities
Emerging MRI and PET Research Reveals Link Between Visceral Abdominal Fat and Early Signs of Alzheimer’s Disease
Reimbursement Challenges in Radiology: An Interview with Richard Heller, MD
Nina Kottler, MD, MS
Practical Insights on CT and MRI Neuroimaging and Reporting for Stroke Patients
Related Content
© 2024 MJH Life Sciences

All rights reserved.