Featured Search - Perfusion CT Predicts Feared Consequences of tPA-Treated Stroke

January 19, 2011

A small study reveals that perfusion CT findings of blood-brain barrier permeability above a specified volume at the time of admission in patients over the age of 65 treated with tPA can predict two “feared complications”-symptomatic hemorrhagic transformation and malignant edema-with 100 percent sensitivity and specificity.

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Blood-Brain Barrier Permeability Assessed by Perfusion CT Predicts Symptomatic Hemorrhagic Transformation and Malignant Edema in Acute Ischemic StrokeAmerican Journal of Neuroradiology | Jan 1, 2011 (FREE FULL TEXT)

A small study headed by a University of Virginia radiologist reveals that perfusion CT findings of blood-brain barrier permeability above a specified volume at the time of admission in patients over the age of 65 treated with tPA can predict two “feared complications”-symptomatic hemorrhagic transformation and malignant edema-with 100 percent sensitivity and specificity. The team hopes these studies can be used to individualize the use of tPA and perhaps extend the time window for its use.

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