MRI contrast agent, gadobenate dimeglumine, safety profile confirmed in 7.5-year trial.
Gadobenate dimeglumine MRI contrast agent has rates of adverse reactions comparable to other gadolinium-based contrast agents, according to a study published in the American Journal of Roentgenology.
Researchers from the University of Pittsburgh Medical Center in Pennsylvania examined the findings of a prospective quality assurance project to determine the incidence of adverse effects with the contrast agent.
During the project, MRI technologists tracked all gadolinium-based contrast administrations at a large tertiary care center and a community hospital with a free-standing cancer treatment center, and any associated adverse reactions, including type of reaction and treatment rendered, between August 1, 2005, and March 14, 2013, a 7.5 year period.
The results showed that 132,252 doses of gadobenate dimeglumine were administered. A total of 236 reactions were recorded (0.18% of contrast-enhanced examinations). Of these, 133 (56.4% of all adverse reactions) required treatment and 12 (5.1%) qualified as serious, per FDA criteria.
The researchers found a significant difference between reaction rates at the academic center (0.23%) and the community hospital (0.07%). The reaction rates were higher in the first two years of study, tapering to a lower baseline rate, which was maintained over more than five years, they noted.
The authors concluded that their study confirmed the relatively robust safety profile of gadobenate dimeglumine.
Emerging AI Algorithm Shows Promise for Abbreviated Breast MRI in Multicenter Study
April 25th 2025An artificial intelligence algorithm for dynamic contrast-enhanced breast MRI offered a 93.9 percent AUC for breast cancer detection, and a 92.3 percent sensitivity in BI-RADS 3 cases, according to new research presented at the Society for Breast Imaging (SBI) conference.
Could AI-Powered Abbreviated MRI Reinvent Detection for Structural Abnormalities of the Knee?
April 24th 2025Employing deep learning image reconstruction, parallel imaging and multi-slice acceleration in a sub-five-minute 3T knee MRI, researchers noted 100 percent sensitivity and 99 percent specificity for anterior cruciate ligament (ACL) tears.
New bpMRI Study Suggests AI Offers Comparable Results to Radiologists for PCa Detection
April 15th 2025Demonstrating no significant difference with radiologist detection of clinically significant prostate cancer (csPCa), a biparametric MRI-based AI model provided an 88.4 percent sensitivity rate in a recent study.