Low-dose CT screening for lung cancer following Lung-RADS criteria may reduce false positives, but it also decreases sensitivity.
Lung cancer screening with low-dose computed tomography may substantially reduce the false-positive result rate, but sensitivity is also decreased, according to a study published in the Annals of Internal Medicine.
Researchers from several states performed a study to assess the retrospective application of the Lung-RADS criteria to the National Lung Screening Trial (NLST).
The study included 26,722 participants (aged 55 to 74) who had undergone three annual low-dose computed tomography (LDCT) scans. The subjects had at least a 30–pack-year history of smoking, and were current smokers or had quit within the past 15 years.
The results showed that 26,455 participants received a baseline screen and 48,671 screenings were performed after baseline.
The researchers concluded that while Lung-RADS may substantially reduce the false-positive result rate, sensitivity is also decreased. They suggest that the effect of using Lung-RADS criteria in clinical practice must be carefully studied.
Stay at the forefront of radiology with the Diagnostic Imaging newsletter, delivering the latest news, clinical insights, and imaging advancements for today’s radiologists.
Study Shows Enhanced Diagnosis of Coronary Artery Stenosis with Photon-Counting CTA
July 10th 2025In a new study comparing standard resolution and ultra-high resolution modes for patients undergoing coronary CTA with photon-counting detector CT, researchers found that segment-level sensitivity and accuracy rates for diagnosing coronary artery stenosis were consistently > 89.6 percent.
Can CT-Based Deep Learning Bolster Prognostic Assessments of Ground-Glass Nodules?
June 19th 2025Emerging research shows that a multiple time-series deep learning model assessment of CT images provides 20 percent higher sensitivity than a delta radiomic model and 56 percent higher sensitivity than a clinical model for prognostic evaluation of ground-glass nodules.