Recent research developments address RFA of the liver

May 10, 2005

Liver RFA is the most well-established indication, as reflected by the number of peer-reviewed reports on this topic: more than 50 between 2003 and 2005. One of the studies included 1000 patients. Reports include general reviews but also address survival rates, comparative studies, evaluation of tumor response, complications, combination therapies, imaging strategies, cost evaluations, and variations in technique.

Authors	Institution	Department	Title	Reference
Atwell TD, Brandhagen DJ, Charboeau JW, Nagoney DM, Callstrom MR, Farrell MA	Mayo Clinic	Radiology	Successful treatment of hepatocellular adenoma with percutaneous radiofrequency ablation	AJR 2005 Mar;184(3):828-831
Bentrem DJ, DeMatteo RP, Blumgart LH	Memorial Sloan-Kettering Cancer Center	Hepatobiliary Service	Surgical therapy for metastatic disease to the liver	Annul Rev Med 2005;56:139-156
Berber E, Rogers S, Siperstein A	Cleveland Clinic	Surgery	Predictors of survival after laparoscopic radiofrequency thermal ablation of hepatocellular cancer: a prospective study	Surg Endosc 2005 Mar 11: Epub ahead of print
Buscarini E, Savoia A, Brambilla G, Menozzi F, Reduzzi L, Stroebel D, Hansler J, Buscarini L, Gaiti L, Zambelli A	Crema, Italy	Gastroenterology	Radiofrequency thermal ablation of liver tumors	Eur Radiol 2005 May;155:884-894
Gillams AR, Lees WR	Middlesex Hosp London	Radiology	Radiofrequency ablation of colorectal liver metastases	Abdom Imaging 2005 Mar 15; Epub ahead of print
Huo TI, Lee SD, Wu JC	Taipei Veterans	Med, Surg, Radiol	Ethanol injection versus radiofrequency ablation for hepatocellular carcinoma: which is better?	Gastroenterol 2005 Mar;128(3):806-807
Jaskolka JD, Asch MR, Kachura JR, Ho CS, Ossip M, Wong F, Sherman M, Grant DR, Greig PD, Galliger S	U Health Network Mt Sinai Hosp	Radiology	Needle tract seeding after radiofrequency ablation of hepatic tumors	J Vasc Interv Radiol 2005 Apr;16(4):485-491
Lencioni R, Della Pina C, Batolozzi C	U Pisa	Radiology	Percutaneous image-guided radiofrequency ablation in the therapeutic management of hepatocellular carcinoma	Abdom Imaging 2005 Jan 20; Epub ahead of print
Llovet JM	U Barcelona	Liver Unit	Updated treatment approach to hepatocellular carcinoma	J Gastroenterol 2005 Mar;40(3):225-235
Lonardo MT, Cannici F, Turtulici G, Fusi M, Battistini G	Genoa	Surgery	Intraoperative radiofrequency ablation: intraductal cooling of the main bile ducts for the prevention of heat damage	Hepatogastroenterology 2005 Mar;52(6):3668-3670
Lu DS, Yu NC, Raman SS, Lassman C, Tong MJ, Britten C, Durazo F, Saab S, Han S, Finn R, Hiatt JR, Busuttil	UCLA	Radiology	Percutaneous radiofrequency ablation of hepatocellular carcinoma as a bridge to liver transplantation	Hepatology 2005 May;41(5):1130-1137
Ng KK, Poon RT	Queen Mary Hosp Hong Kong	Surgery	Radiofrequency ablation for malignant liver tumor	Surg Oncol 2005 Jul;14(1):41-52
Tateishi R, Shiina S, Teratani T, Obi S, Sato S, Koike T, Fujishimma T, Yoshida H, Kawabe T, Omata M	U Tokyo	Gastroenterology	Percutaneous radiofrequency ablation for hepatocellular carcinoma: an analysis of 1000 cases	Cancer 2005 Mar 15:103(6):1201-1209
Varghese T, Daniels MJ	U Wisconsin Madison	Medical Physics	Real-time calibration of temperature estimates during radiofrequency ablation	Ultrason Imaging 2004 Jul;26(3):185-200
Zhou X, Strobel D, Haensler J, Bernatik T	Erlangen-Nurnberg	Ultrasound	Hepatic transit time: indicator of the therapeutic response to radiofrequency ablation of liver tumors	Br J Radiol 2005 May; 78(929):433-436
Abdalla EK, Vauthey JN, Ellis V, Pollock R, Broglio KRR, Hess K, Curley SA.	U Texas MD Anderson Cancer Center	Surgical Oncology	Recurrence and outcomes following hepatic resection, radiofrequency ablation, and combined resection/ablation for colorectal liver metastases	Ann Surg 2004 Jun;239:818-825; discussion 825-827
Anderson CD, Lin WC, Buttemere CR, Washington MK, Mahadevan-Jansen A, Pierce J, Nicoud IB, Pinson CW, Chari RS	Vanderbilt	Surgery	Fluoroscopic spectroscopy accurately detects irreversible cell damage during hepatic radiofrequency ablation	Surgery 2004 Sept;136(3):524-531.
Anderson CD, Lin WC, Buttemere CR, Washington MK, Mahadevan-Jansen A, Pierce J, Nicoud IB, Pinson CW, Chari RS	Vanderbilt	Surgery	Real-time spectroscopic assessment of thermal damage: implications for radiofrequency ablation	J Gastrointest Surg 2004 Sept-Oct;8(6):660-669
Bentrem DJ, DeMatteo RP, Blumgart LH	Memorial Sloan-Kettering Cancer Center	Hepatobiliary Service	Surgical therapy for metastatic disease to the liver	Annu Rev Med 2005;56:139-156
Berber E, Senagore A, Remzi F, Rogers S, Herceg N, Casto K, Siperstein A	Cleveland Clinic	General Surgery	Laparoscopic radiofrequency ablation of liver tumors combined with colorectal procedures	Surg Laparosc Endosc Percutan Tech 2004 Aug;14(4):186-190
Bilchik AJ, Wood TE Allegra DP	John Wayne Cancer Inst	Surgery	Radiofrequency ablation of unresectable hepatic malignancies: lessons learned	The Oncologist 6(1):24-33
Bojalian MO, Machado GR, Swenson R, Reeves ME	Loma Linda	Oncologic Surgery, Surgery	Radiofrequency ablation of liver metastasis from ovarian adenocarcinoma: case report and literature review	Gynecol Oncol 2004 May;93(2):557-560
Curley SA, Marra P, Beaty K, Ellis LM, Vauthey JN, Abdalla EK, Scaife C, Raut C, Wolff R, Choi H, Loyer E, Vallone P, Fiore F, Scordino F, DeRoa V, Orlando R, Pinata S, Daniele B, Izzo F	U Texas MD Anderson Cancer Center	Surgical Oncology	Early and late complications after radiofrequency ablation of malignant liver tumors in 608 patients	Ann Surg 2004 Apr;239(4):450-458 (Comment 459-463)
Exner AA, Weinberg BD, Stowe NT, Gallacher A, Wilson, DL, Haaga JR, Gao J	Case Western Reserve	Radiology	Quantitative computed tomography analysis of local chemotherapy in liver tissue after radiofrequency ablation	Acad Radiol 2004 Dec;11(12):1326-3136
Fisher RA, Maluf D, Cotterell AH, Stravitz T, Wolfe L, Luketic V, Sterling R, Shiffman M, Posner M	MCV	Transplant Surgery	Non-resective ablation therapy for hepatocellular carcinoma: effectiveness measured by intention-to-treat and dropout from liver transplant waiting list	Clin Transplant 2004 Oct:18(5):502-512
Friedman MA, Altemus R, Wood BJ	NCI, NIH	Radiology	Radiofrequency ablation in a previously irradiated liver	J Vasc Interv Radiol 2003 Oct;14(10):1345-1348
Frezza EE	Texas Tech	Surgery	Laparoscopic radiofrequency ablation of solitary hepatic gastrinoma metastases	Dig Dis Sci 2004 Feb;49:224-227
Gazelle GS, McMahon PM, Beinfiled MT, Halpern EF, Weinstein MC	Mass General	Tech Assess/Radiology	Metastatic colorectal carcinoma: cost-effectiveness of percutaneous radiofrequency ablation versus that of hepatic resection	Radiology 2004 Dec 233(3):729-739
Haemmerich D, Lee FT, Schutt DJ, Sampson LA, Webster JG, Fine JP, Mahvi DM	U Wisconsin	Biomed Engineering	Large-volume radiofrequency ablation of ex vivo bovine liver with multiple cooled cluster electrodes	Radiology 2005;Feb 234(2):563-568
Hanna NN	U Kentucky	Cancer Center, General Surgery	Radiofrequency ablation of primary and metastatic hepatic malignancies	Clin Colorectal Cancer 2004 July;4(2):92-100
Hawksworth J, Geisinger K, Zagoria R, Kavanagh P Howerton, R Levine EA, Shen P	Wake Forest	General Surgery	Surgical and ablative treatment for metastatic adenocarcinoma to the liver from unknown primary tumor	Ann Surg 2004 Jun;70(6):512-517
Head HW, Dodd GD III	U Texas San Antonio	Radiology	Thermal ablation for hepatocellular carcinoma	Gastroenterol 2004 Nov;127(5 suppl1):S167-S178
Helton WS	U Illinois	General Surgery	Minimizing complications with radiofrequency ablation for liver cancer: the importance of properly controlled clinical trials and standardized reporting (comments on)	Ann Surg 2004 Apr;239(4):459-463
Hines-Peralta A, Hollander CY, Solazzo S, Horkan C, Liu ZJ, Goldberg SN	Beth Israel Deaconess	Radiology	Hybrid radiofrequency and cryoablation device: preliminary results in an animal model	J Vasc Interv Radiol 2004 Oct;15(10):1111-20.
Johnson EW, Holck PS, Levy AE, Yeh MM, Yeung RS	U Washington Seattle	Surgery	The role of tumor ablation in bridging patients to liver transplantation	Arch Sur 2004 Aug;139(8):825-829, discussion 829-830
Jolesz FA, Hynynen K, McDannold N, Freundlich D, Kopelman D	Brigham and Women's		Noninvasive thermal ablation of hepatocellular carcinoma by using magnetic resonance imaging-guided focused ultrasound	Gastroenterol 2004;127(5)
Kim AW, Littrup PJ, Walther MM, Hvizda J, Wood BJ	Magnuson Clinical Ctr NIH	Radiology	Thermal protection during percutaneous ablation of renal cell carcinoma	J Vasc Interv Radiol 2004 Jul;15(7):753-758
Khajanchee YS, Streeter D, Swanstrom LL, Hansen PD	Legacy Health System	Min Invasive Surgery	A mathematical model for preoperative planning of radiofrequency ablation of hepatic tumors	Surg Endosc 2004 Apr;18(4):696-701
Lencioni R, Cioni D, Crocetti L, Franchiani C, Dell Pina C, Lera J, Bartalozzi C	U Pisa	Interventional Radiology	Early-stage hepatocellular carcinoma in patients with cirrhosis: long term results of percutaneous image-guided radiofrequency ablation	Radiology 2002;234:961-967
Llovet JM	Mt Sinai	Liver Diseases	Treatment of hepatocellular carcinoma	Curr Treat Options Gastroenterol 2004 Dec:7(6):431-441
Lu DSK, Yu NC, Raman SS, Lassman C, Murray K, Tong MJ, Amado RG, Busuttil RW	UCLA	Radiol, Path, Surgery	Radiofrequency ablation of hepatocellular carcinoma: treatment success as defined by histologic examination of the explanted liver	Radiology 2005;234:954-960
McGahan JP			Radiofrequency ablation for hepatocellular carcinoma	J AM Coll Surg.2004 May;198(%):853-4; author replay 854-5
Montgomery RS, Rahal A, Dodd GD 3rd, Leyendecker JR, Hubbard LG	U Texas San Antonio	Medical School	Radiofrequency ablation of hepatic tumors: variability of lesion size using a single ablation device	AJR 2004 Mar;182(3):657-661
Mullen JT, Walsh GL, Abdalla EK, Loyer EM, Curley SA, Vauthy JN	MD Anderson Cancer Ctr	Surgical Oncology	Transdiaphragmatic radiofrequency ablation of liver tumors	J Am Coll Surg 2004 Nov;199(5):826-829
Raman SS, Aziz D, Chang X, Ye M, Sayre J, Lassman C, Lu DS.	UCLA	Radiology	Minimizing central bile duct injury during radiofrequency ablation: use of intraductal chilled saline perfusion -- initial observations from a study	Radiology 2004 Jul;232(1):154-159
Raman SS, Aziz D, Chang X, Sayre J, Lassman C, Lu D	UCLA	Radiology	Minimizing diaphragmatic injury during radiofrequency ablation: efficacy of intraabdominal carbon dioxide insufflation	AJR 2004 Jul;183(1):197-200
Shankar S, vanSonnenberg E, Morrison PR, Tuncali K, Silverman SG	U Massachusetts	Radiology	Combined radiofrequency and alcohol injection for percutaneous hepatic tumor ablation	AJR 2004 Nov;183(5):1425-1429
Shea MC	Connecticut VA Hartford	Digestive Diseases	Radiofrequency ablation: putting the heat on liver cancer	Nursing 2004 Dec;34(12):32
Sofocleous CT, Klein KM, Hubbi B, Brown KT, Weiss SH, Kannarkat G, Hinrichs CR, Contractor D, Bahramipour P, Barone A, Baker SR	UMDNJ	Radiology	Histopathologic evaluation of tissue extracted on the radiofrequency probe after ablation of liver tumors: preliminary findings	AJR 2004 Jul;183:209-213
Thomas KT, Bream PR, Berlin J, Meranze SG, Wright JK, Chari RS	Vanderbilt	Hepatobiliary Surgery and Liver Transplantation	Use of percutaneous drainage to treat hepatic abscess after radiofrequency ablation of metastatic pancreatic adenocarcinoma	Am Surg 2004 Jun;70:496-499
Venook AP	UCSF- Mt Zion Center	Cancer Center	Key research issues in the management of hepatocellular cancer	Cancer Chemother Pharmacol 2004 Sept;54 suppl 1:S87-S90

Ex US of Particular Interest
DeBaere T, Risse O, Kuoch C, Dromain C, Sengel C, Smayra T, Din MCE, Letoublon C, Elias D	Inst Gustave Roussy	Radiology, Surgery	Adverse events during radiofrequency treatment of 582 hepatic tumors	AJR 2003;181:695
Decadt B, Siriwardena AK	Manchester Royal Infirmary		Radiofrequency ablation of liver tumors: systemic review	Lancet Oncol 2004 Sept;5(9):550-560
Livraghi T, Solbiati MF, Meloni GS, Gazelle EF, Halpern EF Goldberg SN,	Ospedale Civile	Radiology	Treatment of focal liver tumors with percutaneous radio-frequency ablation: complications encountered in a multi-center study	Radiology 2003;226:441
Tranberg KG	Lund University	Surgery	Percutaneous ablation of liver tumors	Best Pract Res Clin Gastroenterol 2004 Feb;18(1):125-145