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Recent research developments address RFA of the liver
May 10, 2005
Liver RFA is the most well-established indication, as reflected by the number of peer-reviewed reports on this topic: more than 50 between 2003 and 2005. One of the studies included 1000 patients. Reports include general reviews but also address survival rates, comparative studies, evaluation of tumor response, complications, combination therapies, imaging strategies, cost evaluations, and variations in technique.
Liver RFA is the most well-established indication, as reflected by the number of peer-reviewed reports on this topic: more than 50 between 2003 and 2005. One of the studies included 1000 patients. Reports include general reviews but also address survival rates, comparative studies, evaluation of tumor response, complications, combination therapies, imaging strategies, cost evaluations, and variations in technique.
| Authors | Institution | Department | Title | Reference |
| Atwell TD, Brandhagen DJ, Charboeau JW, Nagoney DM, Callstrom MR, Farrell MA | Mayo Clinic | Radiology | Successful treatment of hepatocellular adenoma with percutaneous radiofrequency ablation | AJR 2005 Mar;184(3):828-831 |
| Bentrem DJ, DeMatteo RP, Blumgart LH | Memorial Sloan-Kettering Cancer Center | Hepatobiliary Service | Surgical therapy for metastatic disease to the liver | Annul Rev Med 2005;56:139-156 |
| Berber E, Rogers S, Siperstein A | Cleveland Clinic | Surgery | Predictors of survival after laparoscopic radiofrequency thermal ablation of hepatocellular cancer: a prospective study | Surg Endosc 2005 Mar 11: Epub ahead of print |
| Buscarini E, Savoia A, Brambilla G, Menozzi F, Reduzzi L, Stroebel D, Hansler J, Buscarini L, Gaiti L, Zambelli A | Crema, Italy | Gastroenterology | Radiofrequency thermal ablation of liver tumors | Eur Radiol 2005 May;155:884-894 |
| Gillams AR, Lees WR | Middlesex Hosp London | Radiology | Radiofrequency ablation of colorectal liver metastases | Abdom Imaging 2005 Mar 15; Epub ahead of print |
| Huo TI, Lee SD, Wu JC | Taipei Veterans | Med, Surg, Radiol | Ethanol injection versus radiofrequency ablation for hepatocellular carcinoma: which is better? | Gastroenterol 2005 Mar;128(3):806-807 |
| Jaskolka JD, Asch MR, Kachura JR, Ho CS, Ossip M, Wong F, Sherman M, Grant DR, Greig PD, Galliger S | U Health Network Mt Sinai Hosp | Radiology | Needle tract seeding after radiofrequency ablation of hepatic tumors | J Vasc Interv Radiol 2005 Apr;16(4):485-491 |
| Lencioni R, Della Pina C, Batolozzi C | U Pisa | Radiology | Percutaneous image-guided radiofrequency ablation in the therapeutic management of hepatocellular carcinoma | Abdom Imaging 2005 Jan 20; Epub ahead of print |
| Llovet JM | U Barcelona | Liver Unit | Updated treatment approach to hepatocellular carcinoma | J Gastroenterol 2005 Mar;40(3):225-235 |
| Lonardo MT, Cannici F, Turtulici G, Fusi M, Battistini G | Genoa | Surgery | Intraoperative radiofrequency ablation: intraductal cooling of the main bile ducts for the prevention of heat damage | Hepatogastroenterology 2005 Mar;52(6):3668-3670 |
| Lu DS, Yu NC, Raman SS, Lassman C, Tong MJ, Britten C, Durazo F, Saab S, Han S, Finn R, Hiatt JR, Busuttil | UCLA | Radiology | Percutaneous radiofrequency ablation of hepatocellular carcinoma as a bridge to liver transplantation | Hepatology 2005 May;41(5):1130-1137 |
| Ng KK, Poon RT | Queen Mary Hosp Hong Kong | Surgery | Radiofrequency ablation for malignant liver tumor | Surg Oncol 2005 Jul;14(1):41-52 |
| Tateishi R, Shiina S, Teratani T, Obi S, Sato S, Koike T, Fujishimma T, Yoshida H, Kawabe T, Omata M | U Tokyo | Gastroenterology | Percutaneous radiofrequency ablation for hepatocellular carcinoma: an analysis of 1000 cases | Cancer 2005 Mar 15:103(6):1201-1209 |
| Varghese T, Daniels MJ | U Wisconsin Madison | Medical Physics | Real-time calibration of temperature estimates during radiofrequency ablation | Ultrason Imaging 2004 Jul;26(3):185-200 |
| Zhou X, Strobel D, Haensler J, Bernatik T | Erlangen-Nurnberg | Ultrasound | Hepatic transit time: indicator of the therapeutic response to radiofrequency ablation of liver tumors | Br J Radiol 2005 May; 78(929):433-436 |
| Abdalla EK, Vauthey JN, Ellis V, Pollock R, Broglio KRR, Hess K, Curley SA. | U Texas MD Anderson Cancer Center | Surgical Oncology | Recurrence and outcomes following hepatic resection, radiofrequency ablation, and combined resection/ablation for colorectal liver metastases | Ann Surg 2004 Jun;239:818-825; discussion 825-827 |
| Anderson CD, Lin WC, Buttemere CR, Washington MK, Mahadevan-Jansen A, Pierce J, Nicoud IB, Pinson CW, Chari RS | Vanderbilt | Surgery | Fluoroscopic spectroscopy accurately detects irreversible cell damage during hepatic radiofrequency ablation | Surgery 2004 Sept;136(3):524-531. |
| Anderson CD, Lin WC, Buttemere CR, Washington MK, Mahadevan-Jansen A, Pierce J, Nicoud IB, Pinson CW, Chari RS | Vanderbilt | Surgery | Real-time spectroscopic assessment of thermal damage: implications for radiofrequency ablation | J Gastrointest Surg 2004 Sept-Oct;8(6):660-669 |
| Bentrem DJ, DeMatteo RP, Blumgart LH | Memorial Sloan-Kettering Cancer Center | Hepatobiliary Service | Surgical therapy for metastatic disease to the liver | Annu Rev Med 2005;56:139-156 |
| Berber E, Senagore A, Remzi F, Rogers S, Herceg N, Casto K, Siperstein A | Cleveland Clinic | General Surgery | Laparoscopic radiofrequency ablation of liver tumors combined with colorectal procedures | Surg Laparosc Endosc Percutan Tech 2004 Aug;14(4):186-190 |
| Bilchik AJ, Wood TE Allegra DP | John Wayne Cancer Inst | Surgery | Radiofrequency ablation of unresectable hepatic malignancies: lessons learned | The Oncologist 6(1):24-33 |
| Bojalian MO, Machado GR, Swenson R, Reeves ME | Loma Linda | Oncologic Surgery, Surgery | Radiofrequency ablation of liver metastasis from ovarian adenocarcinoma: case report and literature review | Gynecol Oncol 2004 May;93(2):557-560 |
| Curley SA, Marra P, Beaty K, Ellis LM, Vauthey JN, Abdalla EK, Scaife C, Raut C, Wolff R, Choi H, Loyer E, Vallone P, Fiore F, Scordino F, DeRoa V, Orlando R, Pinata S, Daniele B, Izzo F | U Texas MD Anderson Cancer Center | Surgical Oncology | Early and late complications after radiofrequency ablation of malignant liver tumors in 608 patients | Ann Surg 2004 Apr;239(4):450-458 (Comment 459-463) |
| Exner AA, Weinberg BD, Stowe NT, Gallacher A, Wilson, DL, Haaga JR, Gao J | Case Western Reserve | Radiology | Quantitative computed tomography analysis of local chemotherapy in liver tissue after radiofrequency ablation | Acad Radiol 2004 Dec;11(12):1326-3136 |
| Fisher RA, Maluf D, Cotterell AH, Stravitz T, Wolfe L, Luketic V, Sterling R, Shiffman M, Posner M | MCV | Transplant Surgery | Non-resective ablation therapy for hepatocellular carcinoma: effectiveness measured by intention-to-treat and dropout from liver transplant waiting list | Clin Transplant 2004 Oct:18(5):502-512 |
| Friedman MA, Altemus R, Wood BJ | NCI, NIH | Radiology | Radiofrequency ablation in a previously irradiated liver | J Vasc Interv Radiol 2003 Oct;14(10):1345-1348 |
| Frezza EE | Texas Tech | Surgery | Laparoscopic radiofrequency ablation of solitary hepatic gastrinoma metastases | Dig Dis Sci 2004 Feb;49:224-227 |
| Gazelle GS, McMahon PM, Beinfiled MT, Halpern EF, Weinstein MC | Mass General | Tech Assess/Radiology | Metastatic colorectal carcinoma: cost-effectiveness of percutaneous radiofrequency ablation versus that of hepatic resection | Radiology 2004 Dec 233(3):729-739 |
| Haemmerich D, Lee FT, Schutt DJ, Sampson LA, Webster JG, Fine JP, Mahvi DM | U Wisconsin | Biomed Engineering | Large-volume radiofrequency ablation of ex vivo bovine liver with multiple cooled cluster electrodes | Radiology 2005;Feb 234(2):563-568 |
| Hanna NN | U Kentucky | Cancer Center, General Surgery | Radiofrequency ablation of primary and metastatic hepatic malignancies | Clin Colorectal Cancer 2004 July;4(2):92-100 |
| Hawksworth J, Geisinger K, Zagoria R, Kavanagh P Howerton, R Levine EA, Shen P | Wake Forest | General Surgery | Surgical and ablative treatment for metastatic adenocarcinoma to the liver from unknown primary tumor | Ann Surg 2004 Jun;70(6):512-517 |
| Head HW, Dodd GD III | U Texas San Antonio | Radiology | Thermal ablation for hepatocellular carcinoma | Gastroenterol 2004 Nov;127(5 suppl1):S167-S178 |
| Helton WS | U Illinois | General Surgery | Minimizing complications with radiofrequency ablation for liver cancer: the importance of properly controlled clinical trials and standardized reporting (comments on) | Ann Surg 2004 Apr;239(4):459-463 |
| Hines-Peralta A, Hollander CY, Solazzo S, Horkan C, Liu ZJ, Goldberg SN | Beth Israel Deaconess | Radiology | Hybrid radiofrequency and cryoablation device: preliminary results in an animal model | J Vasc Interv Radiol 2004 Oct;15(10):1111-20. |
| Johnson EW, Holck PS, Levy AE, Yeh MM, Yeung RS | U Washington Seattle | Surgery | The role of tumor ablation in bridging patients to liver transplantation | Arch Sur 2004 Aug;139(8):825-829, discussion 829-830 |
| Jolesz FA, Hynynen K, McDannold N, Freundlich D, Kopelman D | Brigham and Women's | Noninvasive thermal ablation of hepatocellular carcinoma by using magnetic resonance imaging-guided focused ultrasound | Gastroenterol 2004;127(5) | |
| Kim AW, Littrup PJ, Walther MM, Hvizda J, Wood BJ | Magnuson Clinical Ctr NIH | Radiology | Thermal protection during percutaneous ablation of renal cell carcinoma | J Vasc Interv Radiol 2004 Jul;15(7):753-758 |
| Khajanchee YS, Streeter D, Swanstrom LL, Hansen PD | Legacy Health System | Min Invasive Surgery | A mathematical model for preoperative planning of radiofrequency ablation of hepatic tumors | Surg Endosc 2004 Apr;18(4):696-701 |
| Lencioni R, Cioni D, Crocetti L, Franchiani C, Dell Pina C, Lera J, Bartalozzi C | U Pisa | Interventional Radiology | Early-stage hepatocellular carcinoma in patients with cirrhosis: long term results of percutaneous image-guided radiofrequency ablation | Radiology 2002;234:961-967 |
| Llovet JM | Mt Sinai | Liver Diseases | Treatment of hepatocellular carcinoma | Curr Treat Options Gastroenterol 2004 Dec:7(6):431-441 |
| Lu DSK, Yu NC, Raman SS, Lassman C, Murray K, Tong MJ, Amado RG, Busuttil RW | UCLA | Radiol, Path, Surgery | Radiofrequency ablation of hepatocellular carcinoma: treatment success as defined by histologic examination of the explanted liver | Radiology 2005;234:954-960 |
| McGahan JP | Radiofrequency ablation for hepatocellular carcinoma | J AM Coll Surg.2004 May;198(%):853-4; author replay 854-5 | ||
| Montgomery RS, Rahal A, Dodd GD 3rd, Leyendecker JR, Hubbard LG | U Texas San Antonio | Medical School | Radiofrequency ablation of hepatic tumors: variability of lesion size using a single ablation device | AJR 2004 Mar;182(3):657-661 |
| Mullen JT, Walsh GL, Abdalla EK, Loyer EM, Curley SA, Vauthy JN | MD Anderson Cancer Ctr | Surgical Oncology | Transdiaphragmatic radiofrequency ablation of liver tumors | J Am Coll Surg 2004 Nov;199(5):826-829 |
| Raman SS, Aziz D, Chang X, Ye M, Sayre J, Lassman C, Lu DS. | UCLA | Radiology | Minimizing central bile duct injury during radiofrequency ablation: use of intraductal chilled saline perfusion -- initial observations from a study | Radiology 2004 Jul;232(1):154-159 |
| Raman SS, Aziz D, Chang X, Sayre J, Lassman C, Lu D | UCLA | Radiology | Minimizing diaphragmatic injury during radiofrequency ablation: efficacy of intraabdominal carbon dioxide insufflation | AJR 2004 Jul;183(1):197-200 |
| Shankar S, vanSonnenberg E, Morrison PR, Tuncali K, Silverman SG | U Massachusetts | Radiology | Combined radiofrequency and alcohol injection for percutaneous hepatic tumor ablation | AJR 2004 Nov;183(5):1425-1429 |
| Shea MC | Connecticut VA Hartford | Digestive Diseases | Radiofrequency ablation: putting the heat on liver cancer | Nursing 2004 Dec;34(12):32 |
| Sofocleous CT, Klein KM, Hubbi B, Brown KT, Weiss SH, Kannarkat G, Hinrichs CR, Contractor D, Bahramipour P, Barone A, Baker SR | UMDNJ | Radiology | Histopathologic evaluation of tissue extracted on the radiofrequency probe after ablation of liver tumors: preliminary findings | AJR 2004 Jul;183:209-213 |
| Thomas KT, Bream PR, Berlin J, Meranze SG, Wright JK, Chari RS | Vanderbilt | Hepatobiliary Surgery and Liver Transplantation | Use of percutaneous drainage to treat hepatic abscess after radiofrequency ablation of metastatic pancreatic adenocarcinoma | Am Surg 2004 Jun;70:496-499 |
| Venook AP | UCSF- Mt Zion Center | Cancer Center | Key research issues in the management of hepatocellular cancer | Cancer Chemother Pharmacol 2004 Sept;54 suppl 1:S87-S90 |
| Ex US of Particular Interest | ||||
| DeBaere T, Risse O, Kuoch C, Dromain C, Sengel C, Smayra T, Din MCE, Letoublon C, Elias D | Inst Gustave Roussy | Radiology, Surgery | Adverse events during radiofrequency treatment of 582 hepatic tumors | AJR 2003;181:695 |
| Decadt B, Siriwardena AK | Manchester Royal Infirmary | Radiofrequency ablation of liver tumors: systemic review | Lancet Oncol 2004 Sept;5(9):550-560 | |
| Livraghi T, Solbiati MF, Meloni GS, Gazelle EF, Halpern EF Goldberg SN, | Ospedale Civile | Radiology | Treatment of focal liver tumors with percutaneous radio-frequency ablation: complications encountered in a multi-center study | Radiology 2003;226:441 |
| Tranberg KG | Lund University | Surgery | Percutaneous ablation of liver tumors | Best Pract Res Clin Gastroenterol 2004 Feb;18(1):125-145 |