Recent research developments address RFA of the liver

May 10, 2005

Liver RFA is the most well-established indication, as reflected by the number of peer-reviewed reports on this topic: more than 50 between 2003 and 2005. One of the studies included 1000 patients. Reports include general reviews but also address survival rates, comparative studies, evaluation of tumor response, complications, combination therapies, imaging strategies, cost evaluations, and variations in technique.

Liver RFA is the most well-established indication, as reflected by the number of peer-reviewed reports on this topic: more than 50 between 2003 and 2005. One of the studies included 1000 patients. Reports include general reviews but also address survival rates, comparative studies, evaluation of tumor response, complications, combination therapies, imaging strategies, cost evaluations, and variations in technique.

AuthorsInstitutionDepartmentTitleReference
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Lu DS, Yu NC, Raman SS, Lassman C, Tong MJ, Britten C, Durazo F, Saab S, Han S, Finn R, Hiatt JR, BusuttilUCLARadiologyPercutaneous radiofrequency ablation of hepatocellular carcinoma as a bridge to liver transplantationHepatology 2005 May;41(5):1130-1137
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Anderson CD, Lin WC, Buttemere CR, Washington MK, Mahadevan-Jansen A, Pierce J, Nicoud IB, Pinson CW, Chari RSVanderbiltSurgeryReal-time spectroscopic assessment of thermal damage: implications for radiofrequency ablationJ Gastrointest Surg 2004 Sept-Oct;8(6):660-669
Bentrem DJ, DeMatteo RP, Blumgart LHMemorial Sloan-Kettering Cancer CenterHepatobiliary ServiceSurgical therapy for metastatic disease to the liverAnnu Rev Med 2005;56:139-156
Berber E, Senagore A, Remzi F, Rogers S, Herceg N, Casto K, Siperstein ACleveland ClinicGeneral SurgeryLaparoscopic radiofrequency ablation of liver tumors combined with colorectal proceduresSurg Laparosc Endosc Percutan Tech 2004 Aug;14(4):186-190
Bilchik AJ, Wood TE Allegra DPJohn Wayne Cancer InstSurgeryRadiofrequency ablation of unresectable hepatic malignancies: lessons learnedThe Oncologist 6(1):24-33
Bojalian MO, Machado GR, Swenson R, Reeves MELoma LindaOncologic Surgery, SurgeryRadiofrequency ablation of liver metastasis from ovarian adenocarcinoma: case report and literature reviewGynecol Oncol 2004 May;93(2):557-560
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Exner AA, Weinberg BD, Stowe NT, Gallacher A, Wilson, DL, Haaga JR, Gao JCase Western Reserve RadiologyQuantitative computed tomography analysis of local chemotherapy in liver tissue after radiofrequency ablationAcad Radiol 2004 Dec;11(12):1326-3136
Fisher RA, Maluf D, Cotterell AH, Stravitz T, Wolfe L, Luketic V, Sterling R, Shiffman M, Posner MMCVTransplant SurgeryNon-resective ablation therapy for hepatocellular carcinoma: effectiveness measured by intention-to-treat and dropout from liver transplant waiting listClin Transplant 2004 Oct:18(5):502-512
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Frezza EETexas TechSurgeryLaparoscopic radiofrequency ablation of solitary hepatic gastrinoma metastasesDig Dis Sci 2004 Feb;49:224-227
Gazelle GS, McMahon PM, Beinfiled MT, Halpern EF, Weinstein MCMass GeneralTech Assess/RadiologyMetastatic colorectal carcinoma: cost-effectiveness of percutaneous radiofrequency ablation versus that of hepatic resectionRadiology 2004 Dec 233(3):729-739
Haemmerich D, Lee FT, Schutt DJ, Sampson LA, Webster JG, Fine JP, Mahvi DMU WisconsinBiomed EngineeringLarge-volume radiofrequency ablation of ex vivo bovine liver with multiple cooled cluster electrodesRadiology 2005;Feb 234(2):563-568
Hanna NNU KentuckyCancer Center, General SurgeryRadiofrequency ablation of primary and metastatic hepatic malignanciesClin Colorectal Cancer 2004 July;4(2):92-100
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Shankar S, vanSonnenberg E, Morrison PR, Tuncali K, Silverman SGU MassachusettsRadiologyCombined radiofrequency and alcohol injection for percutaneous hepatic tumor ablationAJR 2004 Nov;183(5):1425-1429
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Ex US of Particular Interest    
DeBaere T, Risse O, Kuoch C, Dromain C, Sengel C, Smayra T, Din MCE, Letoublon C, Elias DInst Gustave RoussyRadiology, SurgeryAdverse events during radiofrequency treatment of 582 hepatic tumorsAJR 2003;181:695
Decadt B, Siriwardena AKManchester Royal Infirmary Radiofrequency ablation of liver tumors: systemic reviewLancet Oncol 2004 Sept;5(9):550-560
Livraghi T, Solbiati MF, Meloni GS, Gazelle EF, Halpern EF Goldberg SN, Ospedale CivileRadiologyTreatment of focal liver tumors with percutaneous radio-frequency ablation: complications encountered in a multi-center studyRadiology 2003;226:441
Tranberg KGLund UniversitySurgeryPercutaneous ablation of liver tumorsBest Pract Res Clin Gastroenterol 2004 Feb;18(1):125-145