The U.S. Preventive Services Task Force for the first time has issued recommendations on genetic counseling and DNA-based testing for a disease.
The U.S. Preventive Services Task Force for the first time has issued recommendations on genetic counseling and DNA-based testing for a disease.
In the Sept. 6 issue of the Annals of Internal Medicine, the USPSTF recommended against routine genetic counseling and DNA testing to detect the presence of BRCA1 and BRCA2 gene mutations that may be associated with breast or ovarian cancers. Women lacking a family history of either breast or ovarian cancer and unlikely to test positive for the mutations should not be referred for testing, according to the report.
The task force did say that physicians should suggest counseling and testing for women with specific family histories that put them at risk. The report found evidence in the scientific literature that women with BRCA1 and BRCA2 mutations can reduce their risk of developing breast or ovarian cancer by mastectomy or oophorectomy. Women may also choose to undergo intensive screening by frequent clinical breast exams and mammography or preventive chemotherapy, but the benefits remain uncertain.
Only about 2% of women have family history that put them at risk for BRCA mutations. Even among women with these mutations, not everyone will actually develop breast or ovarian cancer, the report said.
Members of the task force expressed concern about potential harms involved with genetic testing, including false positives, unnecessary surgery, and job or insurance discrimination. This type of testing can cost thousands of dollars, and insurance coverage varies.
But for the few women with specific family history that puts them at risk, counseling and testing could offer reassurance.
"A woman who gains an understanding of the risk she faces may feel less anxious and have a sense of better control of her future," said task force chair Dr. Ned Calonge. "If the DNA test result is positive, the patient and her physician should take a shared decision-making approach in deciding which preventive measures are appropriate."
For more information from the Diagnostic Imaging archives:
U.K. study strengthens case in support of breast MR screening
Yearly mammograms prove insufficient for BRCA carriers
Genetic testing points to earlier diagnosis in breast and ovarian cancer
MRI-Based AI Radiomics Model Offers 'Robust' Prediction of Perineural Invasion in Prostate Cancer
July 26th 2024A model that combines MRI-based deep learning radiomics and clinical factors demonstrated an 84.8 percent ROC AUC and a 92.6 percent precision-recall AUC for predicting perineural invasion in prostate cancer cases.
Breast MRI Study Examines Common Factors with False Negatives and False Positives
July 24th 2024The absence of ipsilateral breast hypervascularity is three times more likely to be associated with false-negative findings on breast MRI and non-mass enhancement lesions have a 4.5-fold likelihood of being linked to false-positive results, according to new research.
Can Polyenergetic Reconstruction Help Resolve Streak Artifacts in Photon Counting CT?
July 22nd 2024New research looking at photon-counting computed tomography (PCCT) demonstrated significantly reduced variation and tracheal air density attenuation with polyenergetic reconstruction in contrast to monoenergetic reconstruction on chest CT.