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Ultrasound may unlock gates of drug delivery
Ultrasound could one day play a key role in drug delivery, if researchers can harness the ultrasound beam's cavitation effect, which allows drugs to pass through the protective membranes of cells.
Ultrasound could one day play a key role in drug delivery, if researchers can harness the ultrasound beam's cavitation effect, which allows drugs to pass through the protective membranes of cells.
Mark R. Prausnitz, Ph.D., of Georgia Institute of Technology's School of Chemical and Biomolecular Engineering experimented with living prostate cancer and animal cells. He confirmed that the powerful cavitation effect produces enough force to stimulate cell membrane permeability. The holes close down quickly but allow the entry of therapeutic molecules that are 50 nm in diameter, larger than most compounds used for gene therapy (J Ultras Med Bio 2006:32[6]915-924).
The procedure could find future use in systemic therapy in oncology, particularly for large-molecule drugs that cannot easily move through cell membranes.
The Reading Room: Racial and Ethnic Minorities, Cancer Screenings, and COVID-19
November 3rd 2020In this podcast episode, Dr. Shalom Kalnicki, from Montefiore and Albert Einstein College of Medicine, discusses the disparities minority patients face with cancer screenings and what can be done to increase access during the pandemic.
Can Intestinal Ultrasound Provide an Alternative for Evaluating Creeping Fat with Crohn’s Disease?
September 25th 2024Intestinal ultrasound demonstrated an 88.2 percent agreement with computed tomography enterography in characterizing creeping fat in patients with Crohn’s disease, according to new research.
MRI or Ultrasound for Evaluating Pelvic Endometriosis?: Seven Takeaways from a New Literature Review
September 13th 2024While noting the strength of MRI for complete staging of disease and ultrasound’s ability to provide local disease characterization, the authors of a new literature review suggest the two modalities offer comparable results for diagnosing pelvic endometriosis.
