Charles Bankhead

December 01, 2006

Cardiologists impressed by the diagnostic power of PET/CT are beginning to recognize its clinical importance. In sites where the transition from PET to PET/CT has been made, rising cardiac PET imaging volumes have followed.

December 01, 2006

June 04, 2006

Molecular imaging will figure prominently in collaborations among public and private interests to modernize the drug development process and make new therapies available more quickly and at lower cost.

June 04, 2006

PET/CT imaging has evolved in the past five years from an undefined new technology to an invaluable instrument that provides critical information for clinical decision making.

November 04, 2005

November 04, 2005

November 04, 2005

November 02, 2005

CONTEXT: Proteases play a key role in cancer progression because of their involvement in the degradation of the extracellular matrix and basement membranes. In breast cancer, increased expression of cathepsin-B and other thiol proteases has been associated with increased aggressiveness and poor outcomes. Protease-sensing optical probes have been used in a variety of oncologic imaging applications. Dr. Christoph Bremer and colleagues at Massachusetts General Hospital and the University of Muenster in Germany examined the ability of a cathepsin-sensing fluorescent imaging probe to detect spontaneous breast cancer lesions.

November 02, 2005

The search for a more sensitive and specific diagnostic test for prostate cancer has led to the burgeoning field of proteomics, providing unprecedented opportunity to identify potential disease biomarkers. With support from the National Cancer Institute's Early Detection Research Network (EDRN), investigators have been examining and comparing protein patterns in the serum of prostate cancer patients and controls. The EDRN initiative makes use of surface-enhanced laser disorption ionization time-of-flight (SELDI-TOF) mass spectrometry.

November 02, 2005

CONTEXT: Dr. Joanne Kurtzberg, Dr. James M. Provenzale, and colleagues at Duke University prospectively evaluated diffusion-tensor MRI (DTI) anisotropy measurements of white matter regions in Krabbe disease patients treated with stem cell transplantation, a promising new therapeutic approach for a condition that previously had no cure. They compared anisotropy values in infants who underwent stem cell transplantation in the first month of life (before development of clinical signs of Krabbe disease) with those who had the procedure after development of clinical signs of the disease at approximately six months of age.