Study Suggests CT-Guided Injections May Restore Sense of Smell in Patients with Long COVID
Utilizing computed tomography (CT) guidance, researchers have found that performing a minimally invasive anesthetic injection into the stellate ganglia may help address parosmia due to COVID-19, according to study results that will be presented at the annual Radiological Society of North America (RSNA) conference next week.
One of the more commonly known symptoms of COVID-19 is an altered sense of smell, which may linger for months and possibly years among those with Long COVID. However, an emerging computed tomography (CT)-guided and minimally invasive procedure may provide some relief from this condition referred to as parosmia.
In a recent study, which will be presented next week at annual Radiological Society of North America (RSNA) conference in Chicago, researchers assessed the use of a CT-guided stellate ganglion block to stimulate the regional autonomic nervous system. The cohort was comprised of 54 patients referred from an ear, nose, and throat specialist with at least six months of post-COVID parosmia that failed topical and pharmaceutical treatments.
In follow-up data of the 10-minute minimally invasive procedure for 37 patients, 22 patients had improved symptoms one week after the stellate ganglion injection with 18 of those patients reporting significant improvement at one month, according to the researchers. They also noted a mean improvement of 49 percent in parosmia symptoms at three months.
In follow-up data of the stellate ganglion block injection for 37 patients, 22 patients had improved symptoms one week after the injection with 18 of those patients reporting significant improvement at one month, according to the researchers. (Image courtesy of RSNA.)
"The initial patient had a tremendously positive outcome, almost immediately, with continued improvement to the point of symptom resolution at four weeks," noted Adam C. Zoga, M.D., M.B.A., an associate professor of radiology and vice chair for clinical practice at Thomas Jefferson University in Philadelphia. "We have been surprised at some outcomes, including near 100% resolution of phantosmia in some patients, throughout the trial."
The study authors noted that 26 patients in the cohort returned for a contralateral injection approximately six weeks after the first stellate ganglion injection and conceded that it was not effective for those who reported no symptom relief from the first injection.
However, Dr. Zoga pointed out that 86 percent of patients who did respond to the first injections received additional symptom relief with the contralateral injection.
ASCO: Study Reveals Significant Racial/Ethnic Disparities with PSMA PET Use for Patients with mPCa
May 30th 2025Latinx patients with metastatic prostate cancer were 63 percent less likely than non-Hispanic White patients to have PSMA PET scans, according to a study of 550 patients presented at the American Society of Clinical Oncology (ASCO) conference.
CT Perfusion Study Shows Enhanced Detection of Medium Vessel Occlusions with Emerging AI Software
May 21st 2025The Rapid CTP AI software offered 23 percent greater detection of medium vessel occlusions in comparison to the Viz CTP AI software, according to research presented at the European Stroke (Organization) Conference (ESOC).
Can Emerging AI Software Offer Detection of CAD on CCTA on Par with Radiologists?
May 14th 2025In a study involving over 1,000 patients who had coronary computed tomography angiography (CCTA) exams, AI software demonstrated a 90 percent AUC for assessments of cases > CAD-RADS 3 and 4A and had a 98 percent NPV for obstructive coronary artery disease.
