• AI
  • Molecular Imaging
  • CT
  • X-Ray
  • Ultrasound
  • MRI
  • Facility Management
  • Mammography

Follicular Lymphoma


An 84-year-old female presents for asymptomatic screening mammogram. Craniocaudal and MLO views of the right breast on demonstrate stable appearance of an intramammary lymph node in the upper outer quadrant.

History: An 84-year-old female presents for asymptomatic screening mammogram.




Figure 1: Craniocaudal and MLO views of the right breast on demonstrate stable appearance of an intramammary lymph node in the upper outer quadrant.


Figure 2: Craniocaudal and MLO views of the right breast at subsequent one-year follow-up demonstrate increased size of the intramammary lymph node with irregular borders.



















Figure 3: Ultrasound evaluation demonstrated that the lymph node was slightly irregular with increased cortical thickness and was hypervascular. The node was biopsied.













Pathology demonstrated lymphoid tissue proliferation around irregular germinal centers. Immunohistochemistry was performed demonstrating lymphoid follicles in which the germinal center cells were diffusely positive for CD10, BCL-2, and BCL-6 whereas the interfollicular regions were positive for CD20 and negative for CD5, CD43 or cyclin-D1. CD3 highlights the T-cell areas. MIB-1 proliferative index was high in the germinal centers. The results supported the diagnosis of follicular lymphoma.


Mammography is used as a screening test for early detection of breast cancer, however occasionally other malignancies or disease processes can be detected and diagnosed as a result of screening mammography. Primary or secondary lymphoma in the breast is a rare entity.1,2 The estimated incidence of primary breast lymphoma ranges from 0.4 percent to 0.5 percent of all breast malignancies while the incidence of secondary lymphoma is approximately 0.07 percent of all breast malignancies.1,2,3,4

Thomas Cade Raggio, MD, and Erini Makariou, MD, Georgetown Hospital, Washington DC


1. Duncan VE, Reddy VV, Jhala NC, Chhieng DC, Jhala DN. Non-Hodgkin's lymphoma of the breast: a review of 18 primary and secondary cases. Ann Diagn Pathol. 2006;10:144–148. doi: 10.1016/j.anndiagpath.2005.09.018.

2. Domchek SM, Hecht JL, Fleming MD, Pinkus GS, Canellos GP. Lymphomas of the breast: primary and secondary involvement. Cancer. 2002;94:6–13. doi: 10.1002/cncr.10163

3. Vignot S, Ledoussal V, Nodiot P, Bourguignat A, Janvier M, Mounier N, Cherel P, Floiras JL, Turpin F. Non-Hodgkin's lymphoma of the breast: a report of 19 cases and a review of the literature. Clin Lymphoma. 2005;6:37–42.

4. Anuradha Sinha A, Ramrakhiani D. Primary non-Hodgkin's lymphoma of the breast: a case report. Acta Cytol. 2005;49:661–665.

Related Videos
Where the USPSTF Breast Cancer Screening Recommendations Fall Short: An Interview with Stacy Smith-Foley, MD
A Closer Look at MRI-Guided Transurethral Ultrasound Ablation for Intermediate Risk Prostate Cancer
Improving the Quality of Breast MRI Acquisition and Processing
Can Fiber Optic RealShape (FORS) Technology Provide a Viable Alternative to X-Rays for Aortic Procedures?
Does Initial CCTA Provide the Best Assessment of Stable Chest Pain?
Making the Case for Intravascular Ultrasound Use in Peripheral Vascular Interventions
Can Diffusion Microstructural Imaging Provide Insights into Long Covid Beyond Conventional MRI?
Assessing the Impact of Radiology Workforce Shortages in Rural Communities
Emerging MRI and PET Research Reveals Link Between Visceral Abdominal Fat and Early Signs of Alzheimer’s Disease
Reimbursement Challenges in Radiology: An Interview with Richard Heller, MD
Related Content
© 2024 MJH Life Sciences

All rights reserved.