Interventional Radiology-Led Study Shows Significant Limb Salvage Benefits with Transcatheter Arterialization
For patients with no-option chronic limb-threatening ischemia (CLTI), transcatheter arterialization provided over a 25 percent higher amputation-free survival rate over standard medical management at one year, according to research presented at the Society of Interventional Radiology (SIR) Annual Scientific Meeting.
Transcatheter arterialization of the deep veins (TADV) facilitates significantly improved outcomes in patients with chronic limb-threatening ischemia (CLTI) who are not eligible for open or endovascular treatment, according to new research presented at the Society of Interventional Radiology (SIR) Annual Scientific Meeting.
For the study, researchers employed propensity-score matching to compare TADV (LimFlow System, Inari Medical) versus standard medical management in 228 patients with CLTI who were not eligible for open or endovascular treatment (also referred to as patients with “no-option” CLTI).
In new research presented at the Society of Interventional Radiology (SIR) Annual Scientific Meeting, transcatheter arterialization of the deep veins (TADV) provided significantly improved limb salvage, survival and amputation-free survival rates in comparison to standard medical management in patients with no-option chronic limb-threatening ischemia (CLTI).
The study authors found that patients in the TADV cohort had a 16.8 percent higher limb salvage rate (74.6 percent vs. 57.8 percent), a 15.3 percent higher survival rate (86.4 percent vs. 71.1 percent) and a 25.8 percent higher amputation-free survival rate (64.9 percent vs. 39.1 percent).
“TADV was associated with significantly improved limb salvage, survival, and amputation-free survival at 1 year compared to contemporary benchmark for no-option CLTI patients,” wrote lead study author and interventional radiologist Nicholas Petruzzi, M.D., FSVM, DABR, who is affiliated with Atlantic Medical Imaging in New Jersey, and colleagues.
(Editor’s note: For related content, see “Diagnosing Cardiac Ischemia in Women: Key Imaging Considerations,” “What New Computed Tomography Research Reveals About Predicting Diabetes and Cardiometabolic Risks” and “Predicting Diabetes on CT Scans: What New Research Reveals with Pancreatic Imaging Biomarkers.”)
Findings from the research, which garnered “Abstract of the Year” honors with three other abstracts presented at the SIR conference, also revealed that TADV was a cost-effective option that may increase life expectancy in patients with no-option CLTI by more than two years in comparison to standard medical management.
“Over a patient’s lifetime, TADV added 1.09 (quality-adjusted life years) QALYs (2.25 vs 1.16) with a resulting ICER (incremental cost-effectiveness ratio) of $33,011 per QALY gained. The total projected survival gain with TADV was 2.18 life years,” pointed out Petruzzi and colleagues.
Reference
1. Petruzzi N, Clair D, Shishehbor M, Dua A, Pietzsch J. One-year clinical and lifetime cost-effectiveness outcomes of transcatheter arterialization for no-option CLTI in the U.S. J Vasc Interv Radiol. 2025;36(3):S2-S3. Available at: https://www.jvir.org/article/S1051-0443(24)00818-2/fulltext .
Mammography Study Compares False Positives Between AI and Radiologists in DBT Screening
May 8th 2025For DBT breast cancer screening, 47 percent of radiologist-only flagged false positives involved mass presentations whereas 40 percent of AI-only flagged false positive cases involved benign calcifications, according to research presented at the recent American Roentgen Ray Society (ARRS) conference.
MRI Study at ARRS Raises Questions About Disparities in Detection of MASLD
May 3rd 2025New research revealed that Hispanic Americans with evidence of hepatic steatosis on MRI but no formal diagnosis of MASLD had over a fourfold higher risk of developing hepatocellular carcinoma in comparison to those who had a formal diagnosis of MASLD.
FDA Clears MRI-Based AI Segmentation of Organs at Risk During Radiation Therapy
May 2nd 2025Capable of segmenting over 37 organs and structures in the head, neck and pelvis, the MR Contour DL software is currently being showcased at the European Society for Radiotherapy and Oncology (ESTRO) conference.
Study Examines CT-Based AI Detection of Incidental Abdominal Aortic Aneurysms
April 29th 2025The AI software Viz AAA offered a sensitivity of 87.5 percent in detecting abdominal aortic aneurysms on contrast-enhanced CT, according to new retrospective research presented at the American Roentgen Ray Society (ARRS) conference.
