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PIB-PET opens diagnostic front in Alzheimer's disease
Australian researchers using PET imaging with Pittsburgh Compound B found a link between the progressive accumulation of beta-amyloid plaque in the brain and mild cognitive impairment and Alzheimer's disease. Findings could pertain to anti-amyloid drugs now in clinical trials.
Australian researchers using PET imaging with Pittsburgh Compound B found a link between the progressive accumulation of beta-amyloid plaque in the brain and mild cognitive impairment and Alzheimer's disease. Findings could pertain to anti-amyloid drugs now in clinical trials.
Dr. Christopher C. Rowe, director of nuclear medicine at the Austin Hospital's Centre for PET in Melbourne, and colleagues evaluated 44 Alzheimer's patients, 44 patients with mild cognitive impairment, and 34 healthy controls. The trial correlated results from psychometric memory tests and PIB standard uptake values in the frontal, posterior cingulate, parietal, lateral temporal, and occipital brain regions. Researchers found cortical PIB binding in all Alzheimer's patients, 60% of subjects with measurable cognitive deficits, and 20% of healthy volunteers. Findings were presented at the 2007 SNM meeting.
MRI-Based AI Radiomics Model Offers 'Robust' Prediction of Perineural Invasion in Prostate Cancer
July 26th 2024A model that combines MRI-based deep learning radiomics and clinical factors demonstrated an 84.8 percent ROC AUC and a 92.6 percent precision-recall AUC for predicting perineural invasion in prostate cancer cases.
Breast MRI Study Examines Common Factors with False Negatives and False Positives
July 24th 2024The absence of ipsilateral breast hypervascularity is three times more likely to be associated with false-negative findings on breast MRI and non-mass enhancement lesions have a 4.5-fold likelihood of being linked to false-positive results, according to new research.
Can Polyenergetic Reconstruction Help Resolve Streak Artifacts in Photon Counting CT?
July 22nd 2024New research looking at photon-counting computed tomography (PCCT) demonstrated significantly reduced variation and tracheal air density attenuation with polyenergetic reconstruction in contrast to monoenergetic reconstruction on chest CT.
