The ability to image single cells with MRI is analogous to Lindbergh's transatlantic flight to Paris. Just as it is hard to imagine commercial aviation without transoceanic travel, molecular imaging cannot realize its full potential without in vivo imaging of individual cells.
The ability to image single cells with MRI is analogous to Lindbergh's transatlantic flight to Paris. Just as it is hard to imagine commercial aviation without transoceanic travel, molecular imaging cannot realize its full potential without in vivo imaging of individual cells.
Erik M. Shapiro, Ph.D., has demonstrated that it is possible to characterize individual cells in mice with MRI. Primary mouse hepatocytes were double-labeled with 1.63-micron-diameter, polymer-coated iron oxide particles (MPIOs) and a fluorescent cell tracker agent and were then transplanted into the spleens of mice. Optical microscopy showed that most labeled cells contained more than 50 MPIOs. Previous research had demonstrated that the MPIO-labeled cells migrated to the liver and engraft as single cells.
Confocal fluorescent microscopy and in vivo gradient-echo MRI acquired at 100 x 100 x 300-micron resolution were performed a month after transplantation.
Shapiro, now an assistant professor of radiology at New York University School of Medicine, conducted the study in the Laboratory of Functional and Molecular Imaging at the National Institute for Neurological Disorders and Stroke. He presented his findings in May at the International Society for Magnetic Resonance in Medicine meeting in Miami.
Seven Takeaways from Meta-Analysis of PSMA Radiotracers for Prostate Cancer Imaging
December 1st 2023In a newly published meta-analysis of 24 studies, researchers noted that the PSMA PET radiotracer 18F PSMA-1007 may provide more benefit than 68Ga Ga-PSMA-11 for primary staging of patients with prostate cancer and detection of local lesion recurrence, but also has drawbacks with higher liver uptake and multiple reports of false positive bone lesions.
Study: Regular Mammography Screening Reduces Breast Cancer Mortality Risk by More than 70 Percent
November 30th 2023Consistent adherence to the five most recent mammography screenings prior to a breast cancer diagnosis reduced breast cancer death risk by 72 percent in comparison to women who did not have the mammography screening, according to new research findings presented at the annual Radiological Society of North America (RSNA) conference.
FDA Clears Magnetic Resonance Spectroscopy Platform for Non-Invasive Assessment of Brain Chemistry
November 29th 2023BrainSpec Core reportedly offers enhanced sensitivity for low-grade gliomas and may facilitate the diagnosis of conditions including Alzheimer’s disease, multiple sclerosis, and epilepsy.