A 79-year-old man was diagnosed with prostate cancer in 1993 after a transurethral resection of the prostate (TURP). The patient had a Gleason score of 5 and was initially treated with low-dose-rate radioactive seed implants.
A 79-year-old man was diagnosed with prostate cancer in 1993 after a transurethral resection of the prostate (TURP). The patient had a Gleason score of 5 and was initially treated with low-dose-rate radioactive seed implants. PSA values decreased from 10 ng/ml to undetectable levels. In 2004, his PSA began to rise again.
Subsequent CT and Tc-99m methylenephosphonate (MDP) bone scan (see legend) demonstrated osteoblastic metastases within the lumbar spine and pelvis. Multiple enlarged pelvic lymph nodes included a significantly enlarged left iliac chain node (5.3 x 4.8 x 7.7 cm) with clusters of calcification. This enlarged lymph node demonstrated Tc-99m MDP retention on bone scan, likely related to the calcification.
Metastatic prostate cancer.
The exact mechanism of technetium-labeled phosphonate uptake in a bone scan is not completely understood. It is thought that the phosphonate molecule is chemiabsorbed onto the calcium portion of hydroxyapatite, located on the surface of bone.
The major factors affecting this absorption include osteoblastic activity and skeletal vascularity, with preferential uptake at sites of active bone formation. Mechanisms that may lead to increased extraosseous Tc-99m–labeled phosphonate uptake include extracellular fluid expansion, enhanced regional vascularity and permeability, and elevated tissue calcium concentration.
There have been numerous reports of extraosseous Tc-99m–labeled phosphonate accumulation in a variety of clinical settings including hepatic metastases from colon, breast, and other mucinous carcinomas, ganglioneuroblastoma, a benign intrapulmonary calcified focus, plasma cell granuloma, benign cystic teratoma, ovarian carcinoma and its soft tissue metastases, intracranial Sturge-Weber syndrome, cutaneous malignant melanoma metastases in an inguinal lymph node, lymph node metastases of small cell carcinoma of the esophagus, and focal uptake in a gossypiboma (a retained surgical sponge).
Prior to this report, one case of increased phosphonate uptake due to calcification within the prostate has been published. However, to our knowledge, no cases of increased uptake in a patient with metastatic prostate cancer to lymph nodes containing calcification have been reported.
Submitted by Dr. Michael E. Witkosky, Dr. Alan D. Waxman, and Dr. Louise E.J. Thomson, all in the division of nuclear medicine, department of imaging at Cedars-Sinai Medical Center in Los Angeles, CA.
1. Shih WJ, DeLand FH, Domstad PA, Johnston EH. Extraosseous localization of 99mTc-MDP in ganglioneuroblastoma. Eur J Nucl Med 1982;7(7):336-338.
2. Hui C, Lau KK. Intracranial Tc99m MDP uptake in Sturge-Weber syndrome. Australas Radiol 2003;47(1):75-77.
3. Takahasi T, Machida K, Honda N, et al. Extraosseous accumulation of 99mTc-MDP in lymph node metastases of small cell carcinoma of the esophagus. Ann Nucl Med 2004;18(2):157-160.
4. Shih WJ, Domstad PA, Lieber A, et al. Localization of 99mTc-HMDP in hepatic metastases from colonic carcinoma. AJR 1986;146(2):333-336.
5. Baumert JE, Lantieri RL, Horning S, McDougall IR. Liver metastases of breast carcinoma detected on 99mTc-methylene diphosphonate bone scan. Am J Roentgenol 1980;134(2):684-391.
FDA Clears Virtually Helium-Free 1.5T MRI System from Siemens Healthineers
June 26th 2025Offering a cost- and resource-saving DryCool magnet technology, the Magnetom Flow.Ace MRI system reportedly requires 0.7 liters of liquid helium for cooling over the lifetime of the device in contrast to over 1,000 liters commonly utilized with conventional MRI platforms.
SNMMI: Botox May Facilitate Relief from Dry Mouth Side Effect of PSMA-Targeted Radiopharmaceuticals
June 25th 2025For patients being treated with radiopharmaceutical agents for metastatic prostate cancer, the combination of botulinum toxin and an anti-nausea patch led to a 30 percent reduction in PSMA uptake in the salivary glands, according to preliminary research findings presented at the SNMMI conference.
SNMMI: Can 18F-Fluciclovine PET/CT Bolster Detection of PCa Recurrence in the Prostate Bed?
June 24th 2025In an ongoing prospective study of patients with biochemical recurrence of PCa and an initial negative PSMA PET/CT, preliminary findings revealed positive 18F-fluciclovine PET/CT scans in over 54 percent of the cohort, according to a recent poster presentation at the SNMMI conference.