Case History: A 60-year-old male presents with complaints of behavioral changes for 2 months in bipolar disorder.
Behavioral changes for 2 months in bipolar disorder.
Figure 1. Changes of cerebral cortical atrophy and white matter volume loss is noted asymmetrically involving bilateral frontal and temporal lobes on T2WI axial (a), and on T1WI axial (b,c), MRI images (d).
Figure 2. Changes of cerebral cortical atrophy and white matter volume loss is noted asymmetrically involving bilateral frontal and temporal lobes on T1WI MRI images (a), and on T2WI saggital MRI images (b,c,d).
The changes were more prominent in frontal lobes than temporal lobes.
In addition, the degree of frontostriatal dysfunction varies between the different FTLD subgroups, with behavioral variant frontotemporal dementia (bvFTD) having the greatest involvement.
The term Pick disease should probably be avoided when discussing clinical presentation.
A convenient division based on clinical presentation is into behavioral and language variants.
The majority of cases are sporadic, however 20%-40% may relate to an autosomal gene.
