FMRI shows dysfunction in bipolar, ADHD patients
University of Illinois at Chicago researchers using functional MRI found the dorsolateral prefrontal cortex region of the brain is less active in patients with pediatric bipolar disorder and attention deficit hyperactivity disorder than in controls.
University of Illinois at Chicago researchers using functional MRI found the dorsolateral prefrontal cortex region of the brain is less active in patients with pediatric bipolar disorder and attention deficit hyperactivity disorder than in controls. The prefrontal cortex controls behavior such as impulsivity, executive function, and cognitive processes such as working memory, attention, and language.
The researchers imaged children aged 10 to 18 with fMRI as they performed a working memory task. Subjects with bipolar disorder exhibited greater deployment of the emotion-processing circuitry and reduced deployment of working memory circuitry compared with healthy subjects. Commonalities with attention deficit hyperactivity disorder included corticosubcortical activity that was reduced under negative emotional challenge and increased under positive emotional challenge (J Am Acad Child Adolesc Psychiatry 2010;49:1064-1080).
The goal of the research is to develop imaging markers of behavioral illness that can be used in a clinical setting, the authors said.
Could AI-Powered Abbreviated MRI Reinvent Detection for Structural Abnormalities of the Knee?
April 24th 2025Employing deep learning image reconstruction, parallel imaging and multi-slice acceleration in a sub-five-minute 3T knee MRI, researchers noted 100 percent sensitivity and 99 percent specificity for anterior cruciate ligament (ACL) tears.
The Reading Room Podcast: Current Perspectives on the Updated Appropriate Use Criteria for Brain PET
March 18th 2025In a new podcast, Satoshi Minoshima, M.D., Ph.D., and James Williams, Ph.D., share their insights on the recently updated appropriate use criteria for amyloid PET and tau PET in patients with mild cognitive impairment.
