Patients with mild traumatic brain injury (MTBI) exhibit abnormal functional connectivity in the thalamus, a relay station for transmitting information throughout the brain, according to a new fMRI study published online in the journal Radiology. The findings could have implications for treatment strategies.
Patients with mild traumatic brain injury (MTBI) exhibit abnormal functional connectivity in the thalamus, a relay station for transmitting information throughout the brain, according to a new fMRI study published online in the journal Radiology. The findings could have implications for treatment strategies.
Yulin Ge, MD, of the Department of Radiology at NYU Langone Medical Center, and colleagues used resting state functional magnetic resonance imaging (RS-fMRI) to study the brain activity of 24 patients with MTBI and 17 healthy control patients. A normal pattern of thalamic resting state networks (RSNs) with relatively symmetric and restrictive connectivity was demonstrated in the healthy control group. In the patients with MTBI, subtle injury to the thalamus apparently disrupted this pattern, with significantly increased thalamic RSNs and decreased symmetry. The findings correlated with clinical symptoms and diminished neurocognitive functions in the patients with MTBI, the authors said.
Because the causes of post-concussive syndrome are poorly understood, there is currently no treatment. But the authors said the results of this study have implications for a new therapeutic strategy based on sound understanding of the underlying mechanisms of thalamocortical disruption and post-concussive syndrome.
Thalamic functional networks have multiple functions, including sensory information process and relay, consciousness, cognition, and sleep and wakefulness regulation, the authors said. Their disruption of thalamic RSNs may result in a burning or aching sensation, mood swings and sleep disorders, and can contribute to certain psychotic, affective, obsessive-compulsive, anxiety and impulse control disorders. These symptoms are commonly seen in MTBI patients with post-concussive syndrome, they said.
According to the CDC, 1.5 million people sustain traumatic brain injuries in the United States each year. MTBI, or concussion, accounts for at least 75 percent of these injuries. Typically in patients with MTBI, there are no structural abnormalities visible on the brain, so researchers have begun using specialized imaging exams to detect abnormalities in how the brain functions.
“These findings hold promise for better elucidating the underlying cause of a variety of post-traumatic symptoms that are difficult to spot and characterize using conventional imaging methods,” Ge said.
Stay at the forefront of radiology with the Diagnostic Imaging newsletter, delivering the latest news, clinical insights, and imaging advancements for today’s radiologists.
Large Medicare Study Shows Black Men Less Likely to Receive PET and MRI for Prostate Cancer Imaging
August 3rd 2025An analysis of over 749,000 Medicare beneficiaries diagnosed with prostate cancer over a five-year period found that Black men were 13 percent less likely to receive PET imaging and 16 percent less likely to receive MRI in comparison to White men.
The Reading Room Podcast: Current and Emerging Insights on Abbreviated Breast MRI, Part 3
August 3rd 2025In the last of a three-part podcast episode, Stamatia Destounis, MD, Emily Conant, MD and Habib Rahbar, MD, share additional insights on practical considerations and potential challenges in integrating abbreviated breast MRI into clinical practice, and offer their thoughts on future research directions.
The Reading Room Podcast: A Closer Look at Remote MRI Safety, Part 3
August 3rd 2025In the third of a three-part podcast episode, Emanuel Kanal, M.D. and Tobias Gilk, MRSO, MRSE, discuss strategies for maintaining the integrity of time-out procedures and communication with remote MRI scanning.
Study Reveals Significant Prevalence of Abnormal PET/MRI and Dual-Energy CT Findings with Long Covid
August 3rd 2025In a prospective study involving nearly 100 patients with Long Covid, 57 percent of patients had PET/MRI abnormalities and 90 percent of the cohort had abnormalities on dual-energy CT scans.