• AI
  • Molecular Imaging
  • CT
  • X-Ray
  • Ultrasound
  • MRI
  • Facility Management
  • Mammography

‘PET score’ Tops Neuropsych Testing in Tracking Alzheimer’s Progression

Article

Positron emission tomography (PET) scans using F-18 florbetaben (18F-FDG) are more reliable than traditional neuropsychological testing in tracking the evolution of mild cognitive impairment to Alzheimer’s disease, researchers reported in the Journal of Nuclear Medicine.

Positron emission tomography (PET) scans using F-18 florbetaben (18F-FDG) are more reliable than traditional neuropsychological testing in tracking the evolution of mild cognitive impairment to Alzheimer’s disease, researchers reported in the Journal of Nuclear Medicine.

A University of Manchester, U.K., team led by Karl Herholz developed a “PET score” based on scans of 94 patients with mild cognitive impairment (MCI), 40 patients with Alzheimer’s disease, and 44 controls. The subjects, part of the Alzheimer Disease Neuroimaging Initiative (ADNI), received four scans and clinical assessments over two years.

PET scores provided far higher test-retest reliability than standard neuropsychological scores done with the Alzheimer's Disease Assessment Scale-Cognitive (ADAS-cog) and Mini-Mental State Examination. The scores also provided better measurements of progression, Herholz and colleagues found.

At the same time, FDG-PET scans relate directly to ADAS-cog scores, thus providing a valid measure of cognitive impairment. In addition, PET scores of patients who had mild cognitive impairment at the beginning of the study predicted clinical progression to dementia with a higher accuracy than Mini-Mental State Examination and ADAS-cog, the researchers reported.

FDG-PET provides insights into the impairment of synaptic function and could, with appropriate standardization, qualify as a biomarker, the researchers said.

"Prevention of dementia by drugs applied at MCI stage would greatly improve quality of life for patients and reduce costs of dementia care and treatment," Herholz and colleagues wrote.
 

Related Videos
Emerging Research at SNMMI Examines 18F-flotufolastat in Managing Primary and Recurrent Prostate Cancer
Could Pluvicto Have a Role in Taxane-Naïve mCRPC?: An Interview with Oliver Sartor, MD
New SNMMI President Cathy Cutler, PhD, Discusses Current Challenges and Goals for Nuclear Medicine
Where the USPSTF Breast Cancer Screening Recommendations Fall Short: An Interview with Stacy Smith-Foley, MD
A Closer Look at MRI-Guided Transurethral Ultrasound Ablation for Intermediate Risk Prostate Cancer
Improving the Quality of Breast MRI Acquisition and Processing
Can Fiber Optic RealShape (FORS) Technology Provide a Viable Alternative to X-Rays for Aortic Procedures?
Does Initial CCTA Provide the Best Assessment of Stable Chest Pain?
Making the Case for Intravascular Ultrasound Use in Peripheral Vascular Interventions
Can Diffusion Microstructural Imaging Provide Insights into Long Covid Beyond Conventional MRI?
Related Content
© 2024 MJH Life Sciences

All rights reserved.