Patients experience fewer neurologic, motor, and language problems post-surgery.
Incorporating functional MRI (fMRI) into brain tumor resection planning can help reduce the possibility of negative outcomes patients might experience after surgery.
In a study published in the June 1 Radiology, investigators from Johns Hopkins Hospital showed that using fMRI is an effective way to safeguard brain cancer patients health.
“Our result suggests that pre-operative functional (fMRI) mapping results in a lower risk for delayed or permanent neurologic deficits that persists after a two-month follow-up period when compared with surgery without pre-operative fMRI,” said the team led by Licia Luna, M.D., Ph.D., a nuclear medicine fellow with Johns Hopkins Medicine. “It should be considered as the standard-of-care for brain tumor surgery, even with small tumor volumes.”
Currently, fMRI is gaining traction as an effective way to pinpoint tumors and structures in the brain before a patient goes in for surgery, but there is still considerable disagreement over how it’s being used now and what it could potentially do.
MRI scans and direct cortical stimulation technique in a 32-year-old woman with a grade II astrocytoma. Preoperative MRI shows a well-delineated mass within the left frontal lobe on, A, three-dimensional fluid-attenuated inversion recovery and, B, precontrast three-dimensional T1-weighted scan. C, Patchy and faint contrast enhancement is observed on postcontrast three-dimensional T1-weighted MRI scan. D, Cerebral blood volume map shows a globally hypoperfused tumor with hyperperfused foci.
Credit: RSNA
To get a better idea of the role fMRI plays, the team examined post-operative morbidity in patients who have pre-operative fMRI, comparing it to patients who did not have the scan. To do so, they pulled information from 68 studies conducted between 1946 and 2020, involving 3,280 participants. Examined studies focused on four key areas: patients with brain tumors, individuals who had pre-operative fMRI, the usefulness of pre-operative and intra-operative fMRI with resecting cerebral tumors, and report outcomes after a two-month follow-up timeframe.
Based on their assessment, the team determined that patients who underwent pre-operative fMRI mapping were less likely to have neurologic, motor, or language problems post-surgery, and they were also more likely to have higher Karnofsky scores – a 0-to-100 measurement where lower scores indicate a lower chance of surviving a major illness.
In addition, Luna’s team saw that the adverse event rate linked to pre-operative fMRI was nearly half of what occurred in patients who had surgery without it – 11 percent and 21 percent, respectively.
However, the team said, their results should be interpreted with caution, stressing that more work is still needed to move fMRI closer to widespread use.
“Future studies should include clearly defined outcome measures by using objective measurements and scales and standardizing the definition of permanent neurologic deficits,” they said. “A critical next step toward clinical acceptance of fMRI will be to develop a comprehensive set of guidelines that specifies where and when to implement fMRI in the preoperative planning of neurosurgical oncology.”
For more coverage based on industry expert insights and research, subscribe to the Diagnostic Imaging e-Newsletter here.
Stay at the forefront of radiology with the Diagnostic Imaging newsletter, delivering the latest news, clinical insights, and imaging advancements for today’s radiologists.
Large Medicare Study Shows Black Men Less Likely to Receive PET and MRI for Prostate Cancer Imaging
August 1st 2025An analysis of over 749,000 Medicare beneficiaries diagnosed with prostate cancer over a five-year period found that Black men were 13 percent less likely to receive PET imaging and 16 percent less likely to receive MRI in comparison to White men.
The Reading Room Podcast: A Closer Look at Remote MRI Safety, Part 3
August 1st 2025In the third of a three-part podcast episode, Emanuel Kanal, M.D. and Tobias Gilk, MRSO, MRSE, discuss strategies for maintaining the integrity of time-out procedures and communication with remote MRI scanning.
The Reading Room Podcast: A Closer Look at Remote MRI Safety, Part 2
August 1st 2025In the second of a multi-part podcast episode, Emanuel Kanal, M.D. and Tobias Gilk, MRSO, MRSE, share their perspectives on remote MRI safety protocols for ensuring screening accuracy and adherence to conditional implant guidelines as well as a rapid and effective response to adverse events.
Study Reveals Significant Prevalence of Abnormal PET/MRI and Dual-Energy CT Findings with Long Covid
August 1st 2025In a prospective study involving nearly 100 patients with Long Covid, 57 percent of patients had PET/MRI abnormalities and 90 percent of the cohort had abnormalities on dual-energy CT scans.