Wengen Chen, MD, PhD

A noninvasive technique to detect vulnerable atherosclerotic plaque is critically needed. Formation of atherosclerotic plaque is a dynamic inflammatory process that involves interactions between atherogenic lipoproteins and macrophages. As vulnerable plaques are usually numerous, extending beyond the culprit plaque and involving multiple vessels, targeting a single plaque underestimates the complexity and extent of disease. Thus, an ideal imaging modality should be able to identify the vulnerable arterial bed and, therefore, the vulnerable patient, to prevent the serious complications of atherosclerosis.