Mammography Study Shows Advantages of DBT Guidance for Breast Biopsies

Emerging research demonstrates that digital breast tomosynthesis (DBT)-guided biopsies have significantly shorter procedure times and reduced radiation exposure in comparison to biopsy procedures performed with digital mammography (DM) guidance.

For the retrospective study, recently published in the European Journal of Radiology, researchers reviewed stereotactic biopsy data for 1,645 patients (total of 1,756 biopsies) who had suspicious calcifications. Digital mammography guidance was utilized for 76 percent of the biopsy procedures and DBT guidance was employed in 24 percent of the cases, according to the study.

The researchers found that DBT-guided biopsies required less time (14 minutes) than DM-guided biopsies (15 minutes). In comparison to those who had DM-guided biopsy procedures, the study authors pointed out that patients who had DBT-guided biopsies had significantly reduced radiation exposures (5.7 vs. 8.6) and lower radiation dosing (13 mGy vs. 15 mGy).

The study authors pointed out that DM-guided biopsies and DBT-guided biopsies had the same malignancy rate at 16 percent.

“ … There were no significant differences in the histopathologic outcomes between the two methods, including the final malignancy rates, suggesting that DBT-guided biopsies are equally effective while offering advantages in terms of efficiency and radiation safety,” noted lead study author Eralda Mema, M.D., who is affiliated with the Department of Radiology at Weill Cornell Medicine in New York City, and colleagues.

The researchers noted that shorter procedure times and 2 mGy reduction in average radiation dose with DBT guidance can reduce the “considerable discomfort” associated with stereotactic biopsy procedures and ease patient fears about radiation exposure.

“This could provide added reassurance to patients concerned about radiation during mammographic-guided procedures and potentially improve future compliance with screening mammography,” added Mema and colleagues.

(Editor’s note: For related content, see “FDA Clears AI-Powered Triage Platform for Digital Breast Tomosynthesis,” “Current Perspectives on Digital Breast Tomosynthesis in Women with Dense Breasts” and “Mammography Study: Multi-Stage Use of AI for DBT Exams Yields Over 21 Percent Increase in Breast Cancer Detection.”)

Beyond the inherent limitations of a single-center retrospective study, the authors conceded a lack of randomization for the choice of modality for biopsy guidance and that approximately 75 percent of the biopsies in the study were performed with DM guidance. The researchers also noted the reduced likelihood of post-fire images being obtained for DBT-guided biopsies and the exclusion of patients who had multiple biopsies in the same breast for suspicious calcifications.