The brains of 24 retired U.S. National Football League players with known cognitive impairment show signs of damaging atrophy, according to advanced MRI studies described at the 2009 RSNA annual meeting.
The brains of 24 retired U.S. National Football League players with known cognitive impairment show signs of damaging atrophy, according to advanced MRI studies described at the 2009 RSNA annual meeting.
Songyuan Tang, Ph.D., a postdoctoral researcher associated with University of North Carolina's Biomedical Research Imaging Center, presented preliminary imaging findings that represent the latest steps in research by principal investigator Kevin Guskiewicz, Ph.D., to study the relationship between football-related concussions and cognitive and behavioral problems that emerge long after the men's playing days are over. The findings were drawn from ongoing research conducted by Guskiewicz and colleagues at UNC's Center for the Study of Retired Athletes.
Guskiewicz first drew interest to football-related concussions and dementia in 2005 with a study suggesting that a history of three or more concussions was associated with an increased risk of cognitive impairment by age 50. An autopsy study, published by a different group in 2005, found concentrations of tau protein suggesting dementia in the brains of eight of nine former football players.
Guskiewicz and colleagues also published a study of 2552 retired pro football players in 2007. It revealed that retired NFL players with a history of three of more concussions also had a threefold increased risk of clinical depression after the age of 50 compared with age-matched controls.
Results from Guskiewicz's group presented at the RSNA meeting don't bode well for the 24 retired NFL players, all over age 50, who volunteered for an imaging trial involving structural MRI and diffusion tensor imaging (DTI), an advanced MRI technique that maps connections between neurons. The brain studies of the retired players were compared with identical studies performed on 12 cognitively normal men in the same age group. The retired players had an average of 12 years of combined NFL and collegiate football experience.
Based on T1-weighted imaging, researchers found diffused atrophies in the whole brains of the players (see figure). Mild-to-moderate gray matter atrophy was identified in the eight brain regions for the former players.
In terms of white matter differences, fractional anisotropy DTI maps identified clusters of atrophy in five regions: the inferior frontal-occipital fasciculus, genu, sagittal stratum, posterior corona radiata, and splenium.
By applying fiber tractography to scans of one of the NFL subjects and a normal volunteer, researchers found a marked reduction in the number of fiber connections between neurons in the white matter of the left and right hemispheres of the former football player's brain. The affected regions included the genu, sagittal stratum, and splenium.
“Imaging addresses one piece of a larger puzzle,” Guskiewicz said in an interview. “Along with the behavioral and psychological testing we're doing, imaging is helping us improve football safety.”
Stay at the forefront of radiology with the Diagnostic Imaging newsletter, delivering the latest news, clinical insights, and imaging advancements for today’s radiologists.
Large Medicare Study Shows Black Men Less Likely to Receive PET and MRI for Prostate Cancer Imaging
August 2nd 2025An analysis of over 749,000 Medicare beneficiaries diagnosed with prostate cancer over a five-year period found that Black men were 13 percent less likely to receive PET imaging and 16 percent less likely to receive MRI in comparison to White men.
The Reading Room Podcast: Current and Emerging Insights on Abbreviated Breast MRI, Part 3
August 2nd 2025In the last of a three-part podcast episode, Stamatia Destounis, MD, Emily Conant, MD and Habib Rahbar, MD, share additional insights on practical considerations and potential challenges in integrating abbreviated breast MRI into clinical practice, and offer their thoughts on future research directions.
The Reading Room Podcast: A Closer Look at Remote MRI Safety, Part 3
August 2nd 2025In the third of a three-part podcast episode, Emanuel Kanal, M.D. and Tobias Gilk, MRSO, MRSE, discuss strategies for maintaining the integrity of time-out procedures and communication with remote MRI scanning.
Study Reveals Significant Prevalence of Abnormal PET/MRI and Dual-Energy CT Findings with Long Covid
August 2nd 2025In a prospective study involving nearly 100 patients with Long Covid, 57 percent of patients had PET/MRI abnormalities and 90 percent of the cohort had abnormalities on dual-energy CT scans.