A 48-year-old female presented with complaint of seizures. Reformatted sagittal plain CT scan image of the brain has been provided.

Reformatted sagittal plain CT scan image of the brain showed a well-defined, hypodense curvillinear lesion along the corpus callosum which has an attenuation similar to that of fat (Avg HU value: -80HU).

Corpus callosal lipoma or pericallosal lipoma is the most common location for an intracranial lipoma. It can be asymptomatic; however 50% of patients present with convulsions.


The classic appearance is that of a midline lesion along the corpus callosum that has appearance similar to that of fat on all imaging modalities. USG shows a hyperechoic lesion in the midline, while on CT the lesion appears hypodense with no post-contrast enhancement. On MRI, the lesion is hyperintense on T1W/T2W images, and gets suppressed on fat saturated sequences. Morphologically pericallosal lipomas can be either tubulonodular or curvilinear. Tubulonodular lipomas are anterior, larger in size, and are associated with other fronto-facial anomalies, while the curvilinear variety are located posteriorly and are thin and elongated.


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2. Tart RP, Quisling RG. Curvilinear and tubulonodular varieties of lipoma of the corpus callosum: an MR and CT study. 

3. Dean B, Drayer BP, Beresini DC, et al. MR imaging of pericallosal lipoma. 

4. Bourekas EC, Varakis K, Bruns D, et al. Lesions of the corpus callosum: MR imaging and differential considerations in adults and children. 

5. Desai P, Weerakkody Y. Pericallosal lipoma. Available at: 

http://radiopaedia.org/articles/pericallosal-lipoma

48-year-old female presented with complaint of seizures. 

Image IQ: 48-year-old Female, Complaint of Seizures